cADP-Ribose (cADPR) (CAS 119340-53-3)
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cADP-Ribose (cADPR), a nicotamide adenine dinucleotide (NAD+) metabolite, is an agent that can be found in sea urchin eggs and may act to mobilize intracellular Ca2+ stores of the eggs. Additionally, in a study on pancreatic beta cells, cADP-Ribose (cADPR) was found to be generated in islets by glucose stimulation, and served as a second messenger for calcium mobilization in the endoplasmic reticulum. Other experiments have reported cADP-Ribose to be a signaling molecule in abscisic acid response in plants, which mediates plant responses to stresses such as salinity, cold, and drought. cADP-Ribose (cADPR)′s role in calcium signaling pathways is useful for dissecting the mechanisms by which cells regulate calcium levels and respond to stimuli.
cADP-Ribose (cADPR) (CAS 119340-53-3) References
- cADP ribose and [Ca(2+)](i) regulation in rat cardiac myocytes. | Prakash, YS., et al. 2000. Am J Physiol Heart Circ Physiol. 279: H1482-9. PMID: 11009432
- cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells. | Yusufi, AN., et al. 2001. Am J Physiol Renal Physiol. 281: F91-F102. PMID: 11399650
- A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity. | Graeff, R. and Lee, HC. 2002. Biochem J. 361: 379-84. PMID: 11772410
- Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell function. | Guse, AH. 2002. Curr Mol Med. 2: 273-82. PMID: 12041730
- [ADP-ribose and cADP-ribose--endogenous regulators of cellular ionic balance. Cardiotropic effects of ADP-ribose]. | Kuz'min, VS., et al. 2006. Usp Fiziol Nauk. 37: 3-17. PMID: 16522000
- Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. | Lee, HC., et al. 1989. J Biol Chem. 264: 1608-15. PMID: 2912976
- Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? | Fliegert, R., et al. 2020. Front Immunol. 11: 2018. PMID: 32903769
- NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. | Xie, N., et al. 2020. Signal Transduct Target Ther. 5: 227. PMID: 33028824
- Antiviral activity of bacterial TIR domains via immune signalling molecules. | Ofir, G., et al. 2021. Nature. 600: 116-120. PMID: 34853457
- CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology. | Takasawa, S. 2022. Int J Mol Sci. 23: PMID: 35457121
- Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. | Manik, MK., et al. 2022. Science. 377: eadc8969. PMID: 36048923
- Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. | Takasawa, S., et al. 1993. Science. 259: 370-3. PMID: 8420005
- Regulation of cADP-ribose-induced Ca2+ release by Mg2+ and inorganic phosphate. | Guse, AH., et al. 1996. J Biol Chem. 271: 23946-53. PMID: 8798627
- Ectocellular in vitro and in vivo metabolism of cADP-ribose in cerebellum. | De Flora, A., et al. 1996. Biochem J. 320 (Pt 2): 665-71. PMID: 8973582
- Abscisic acid signaling through cyclic ADP-ribose in plants. | Wu, Y., et al. 1997. Science. 278: 2126-30. PMID: 9405349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cADP-Ribose (cADPR), 500 µg | sc-201512 | 500 µg | $328.00 |