CAB39L Antibody (Q32): sc-100390

CAB39L Antibody (Q32) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAB39L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CAB39L antibody (Q32) is available as a non-conjugated format. CAB39L protein, also known as calcium binding protein 39-like, plays a crucial role in regulating serine/threonine kinase LKB1, which is essential for maintaining cellular energy homeostasis and tumor suppression. LKB1 is activated through interaction with STRAD alpha pseudo kinase and CAB39L protein, forming a complex that facilitates LKB1 translocation from nucleus to cytoplasm. This localization is vital as LKB1 can exert tumor suppressor functions effectively, and dysregulation of this process can lead to conditions such as Peutz-Jeghers Syndrome, characterized by increased risk of various cancers. Notably, CAB39L has been implicated in carcinogenesis, as CAB39L is found in serum of nearly half of patients diagnosed with acute monocytic leukemia, highlighting potential as a biomarker for cancer progression. CAB39L (Q32) monoclonal antibody′s ability to detect CAB39L across multiple species and applications makes this reagent invaluable for researchers studying cancer biology and cellular signaling pathways.

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CAB39L Antibody (Q32) References:

1. Serological identification of immunogenic antigens in acute monocytic leukemia.  |  Chen, G., et al. 2005. Leuk Res. 29: 503-9. PMID: 15755502
2. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.  |  Jenne, DE., et al. 1998. Nat Genet. 18: 38-43. PMID: 9425897
3. LKB1 tumor suppressor protein: PARtaker in cell polarity.  |  Baas, AF., et al. 2004. Trends Cell Biol. 14: 312-9. PMID: 15183188
4. Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle.  |  Taylor, EB., et al. 2004. Am J Physiol Endocrinol Metab. 287: E1082-9. PMID: 15292028
5. Analysis of the LKB1-STRAD-MO25 complex.  |  Boudeau, J., et al. 2004. J Cell Sci. 117: 6365-75. PMID: 15561763
6. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.  |  Taylor, EB., et al. 2005. Am J Physiol Endocrinol Metab. 288: E1055-61. PMID: 15644453
7. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.  |  Jaleel, M., et al. 2005. FEBS Lett. 579: 1417-23. PMID: 15733851

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAB39L Antibody (Q32) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-CAB39L Antibody (Q32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAB39L Antibody (Q32) Specifications

Alternate Product Name: CAB39L

Product Clone Name: Q32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-367

Epitope Target: CAB39L

Epitope Species: human

Product Reactivity/Detection: CAB39L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for CAB39L Antibody (Q32): N/A