CAA0225
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CAA0225 is an epoxysuccinyl peptide and highly selective rat liver cathepsin L inhibitor (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B in vitro. This selectivity makes CAA0225 particularly useful for probing the role of cathepsin L in various cellular processes, including autophagic proteolysis. Autophagy, a critical cellular catabolic pathway responsible for the degradation of cell organelles and proteins during conditions such as nutrient deprivation, is one area where CAA0225 has been applied to distinguish the contributions of cathepsin L from other proteinases like cathepsin B. During autophagy, it is through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
CAA0225 References
- Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis. | Takahashi, K., et al. 2009. Biol Pharm Bull. 32: 475-9. PMID: 19252298
- A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells. | Ueno, T. and Takahashi, K. 2009. Autophagy. 5: 878-9. PMID: 19535915
- Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. | Steverding, D., et al. 2012. Int J Parasitol. 42: 481-8. PMID: 22549023
- Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. | Hensley, HH., et al. 2012. Neoplasia. 14: 451-62. PMID: 22787427
- Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. | Teigler, JE., et al. 2014. J Virol. 88: 10354-63. PMID: 24991003
- Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors. | Steverding, D. 2015. Exp Parasitol. 151-152: 28-33. PMID: 25662707
- Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein. | Zhu, H., et al. 2015. Muscle Nerve. 52: 852-8. PMID: 25703692
- Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. | He, W., et al. 2022. Cardiovasc Res. 118: 1535-1547. PMID: 34132807
- Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling. | Xu, T., et al. 2022. J Med Chem. 65: 4590-4599. PMID: 35275639
- Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies. | Ganassi, M. and Zammit, PS. 2022. Eur J Transl Myol. 32: PMID: 35302338
- Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice. | Liao, MC., et al. 2022. Clin Sci (Lond). 136: 715-731. PMID: 35502764
- Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion. | Branco, LM., et al. 2022. Cell Death Dis. 13: 1029. PMID: 36481780
- Mmp-induced fat body cell dissociation promotes pupal development and moderately averts pupal diapause by activating lipid metabolism. | Jia, Q. and Li, S. 2023. Proc Natl Acad Sci U S A. 120: e2215214120. PMID: 36574695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAA0225, 1 mg | sc-364669 | 1 mg | $311.00 |