CA-074 methyl ester CAS: 147859-80-1
MF: C19H31N3O6
MW: 397.47
A cell-permeable cathepsin B inhibitor.

CA-074 methyl ester (CAS 147859-80-1)

CA-074 methyl ester | CAS 147859-80-1 is rated 5.0 out of 5 by 1.
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Synonym: Cathepsin B inhibitor IV; (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester; N-(L-3-trans-Propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
Application: A cell-permeable cathepsin B inhibitor
CAS Number: 147859-80-1
Molecular Weight: 397.47
Molecular Formula: C19H31N3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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CA-074 methyl ester is a cell-permeable analog of CA-074 (sc-202513) that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone reabsorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.


References

1. Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299: 377-380. PMID: 1444478
2. Montaser, M., et al. 2002. Biol. Chem. 383: 1305-1308. PMID: 12437121

Appearance :
Powder
Physical State :
Solid
Storage :
Store at -20° C
Optical Activity :
-33.3 - -12.1°
c = 1.4 in EtOH, 20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23760717
MDL Number :
MFCD03452890
SMILES :
CCCNC(=O)[[email protected]@H]1[[email protected]](O1)C(=O)N[[email protected]@H](C(C)CC)C(=O)N2CCC[[email protected]]2C(=O)OC

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Certificate of Analysis

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CA-074 methyl ester  Product Citations

See how others have used CA-074 methyl ester. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

PMID: # 27840291  Tylichová, Z. et al. 2017. J. Nutr. Biochem. 39: 145-155.

PMID: # 26911557  Li, W. et al. 2016. BMC Vet. Res. 12: 36.

PMID: # 27729455  2016. J. Biol. Chem. 291: 24779-24786.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Zhang Zhang, L. et al. (PubMed 25384123) found that treatment with CA-074 methyl ester, a cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. -SCBT Publication Review
Date published: 2015-05-15
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