Molecular structure of CA-074 methyl ester, CAS Number: 147859-80-1
CA-074 methyl ester (CAS 147859-80-1)
See product citations (7)
Alternate Names:
Cathepsin B inhibitor IV; (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester; N-(L-3-trans-Propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
Application:
CA-074 methyl ester is a cell-permeable cathepsin B inhibitor
CAS Number:
147859-80-1
Molecular Weight:
397.47
Molecular Formula:
C19H31N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CA-074 methyl ester is a cell-permeable analog of CA-074 (sc-202513) that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone reabsorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. CA-074 demonstrated the ability to eliminate the neurotoxic effects induced by Abeta42-activated BV2 cells. Moreover, the administration of CA-074 resulted in the suppression of immune responses triggered by external antigens, including hepatitis B virus antigen, ovalbumin, and Leishmania major antigen. This suppression led to a shift in helper T cell responses from Th-2 to Th-1 in CD4+ T cells.
CA-074 methyl ester (CAS 147859-80-1) References
- An intracellular form of cathepsin B contributes to invasiveness in cancer. | Szpaderska, AM. and Frankfater, A. 2001. Cancer Res. 61: 3493-500. PMID: 11309313
- CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. | Montaser, M., et al. 2002. Biol Chem. 383: 1305-8. PMID: 12437121
- CA074 methyl ester: a proinhibitor for intracellular cathepsin B. | Buttle, DJ., et al. 1992. Arch Biochem Biophys. 299: 377-80. PMID: 1444478
- Delivery of substances and their target-specific topical activation. | Pipkorn, R., et al. 2006. Biochim Biophys Acta. 1758: 606-10. PMID: 16730647
- Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity. | Sanchez, A. 2007. J Infect Dis. 196 Suppl 2: S251-8. PMID: 17940957
- The mechanism of Axl-mediated Ebola virus infection. | Shimojima, M., et al. 2007. J Infect Dis. 196 Suppl 2: S259-63. PMID: 17940958
- Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice. | Amritraj, A., et al. 2009. Am J Pathol. 175: 2540-56. PMID: 19893049
- Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation. | de Mingo, Á., et al. 2016. Cell Death Dis. 7: e2464. PMID: 27831566
- Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways. | Zhao, P., et al. 2021. PLoS Negl Trop Dis. 15: e0009304. PMID: 33798196
- Dual-locking nanoprobe based on hemicyanine for orthogonal stimuli-triggered precise cancer imaging and therapy. | Zong, Q., et al. 2021. J Control Release. 338: 307-315. PMID: 34454962
- Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells. | Hashimoto, R., et al. 2021. Mol Ther Nucleic Acids. 26: 1107-1114. PMID: 34692233
- Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome. | Wang, J., et al. 2021. Front Cell Infect Microbiol. 11: 769777. PMID: 34869071
- NLRP3 inflammasome activation determines the fibrogenic potential of PM2.5 air pollution particles in the lung. | Cao, W., et al. 2022. J Environ Sci (China). 111: 429-441. PMID: 34949371
Inhibitor of:
cathepsin B, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA-074 methyl ester, 5 mg | sc-214647 | 5 mg | $400.00 |