Molecular structure of C5a Receptor Antagonist, W-54011, CAS Number: 405098-33-1
C5a Receptor Antagonist, W-54011 (CAS 405098-33-1)
See product citations (7)
Alternate Names:
N-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
Application:
C5a Receptor Antagonist, W-54011 is a specific and potent C5a receptor antagonist
CAS Number:
405098-33-1
Purity:
≥95%
Molecular Weight:
493.09
Molecular Formula:
C30H36N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C5a Receptor Antagonist, W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 muM. Shown to prevent C5a-induced neutrophenia in gerbils (100 mug/kg i.v. or 3-30 mg/kg orally).
C5a Receptor Antagonist, W-54011 (CAS 405098-33-1) References
- Identification of a potent and orally active non-peptide C5a receptor antagonist. | Sumichika, H., et al. 2002. J Biol Chem. 277: 49403-7. PMID: 12384495
- C5a promotes migration, proliferation, and vessel formation in endothelial cells. | Kurihara, R., et al. 2010. Inflamm Res. 59: 659-66. PMID: 20217457
- Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis. | Sendler, M., et al. 2015. Gastroenterology. 149: 765-76.e10. PMID: 26001927
Inhibitor of:
CD88, and MPO.Activator of:
C3aR, C8β, LECT2, and Neutrophil Elastase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C5a Receptor Antagonist, W-54011, 1 mg | sc-203863 | 1 mg | $202.00 | |||
C5a Receptor Antagonist, W-54011, 5 mg | sc-203863A | 5 mg | $632.00 |