Date published: 2026-5-25

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C4 Dihydroceramide (CAS 202467-76-3)

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CAS Number:
202467-76-3
Molecular Weight:
371.60
Molecular Formula:
C22H45NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C4 Dihydroceramide, known by its CAS number 202467-76-3, is a synthetic analog of naturally occurring ceramides, which are integral components of the lipid bilayer of cell membranes and play a crucial role in cellular signaling, particularly in the pathways related to apoptosis and cell differentiation. Distinguished by the presence of a saturated fatty acid chain, typically of medium length, C4 Dihydroceramide differs from classical ceramides due to the absence of a double bond in the sphingosine backbone, which imparts unique biophysical properties to the lipid. In research contexts, C4 Dihydroceramide has been extensively used as a tool to dissect the complex lipid signaling pathways that govern cell behavior. Investigations utilizing this compound help explain the mechanisms by which ceramides influence membrane dynamics, including membrane microdomain (often referred to as lipid raft) formation and the regulation of signaling cascades that impact cellular fate. Moreover, studies involving C4 Dihydroceramide contribute to a broader understanding of lipid-mediated interactions within cells, offering insights into how alterations in lipid composition can affect cellular structure and function. Thus, this chemical serves as a valuable probe in the study of lipidomics and membrane biology, providing a deeper understanding of the fundamental processes that underpin cell physiology and pathology without directly referencing its use in any kind of human application scenarios.


C4 Dihydroceramide (CAS 202467-76-3) References

  1. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.  |  Van Overloop, H., et al. 2007. Biol Chem. 388: 315-24. PMID: 17338639
  2. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).  |  Caohuy, H., et al. 2014. J Biol Chem. 289: 35953-68. PMID: 25384981

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C4 Dihydroceramide, 5 mg

sc-210993
5 mg
$320.00