C3 Antibody (2898): sc-52629
- C3 Antibody (2898) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against the C-terminus of C3 of human origin
- recommended for detection of the C-terminus of C3a and intact C3 of human origin by WB and IP
- See C3 (B-9): sc-28294 for C3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for C3 Antibody (2898). This work is in progress.
C3 Antibody (2898) is a mouse monoclonal IgG1 antibody raised against the C-terminus of the human Complement Component 3 (C3) protein. C3, also known as CPAMD1 or acylation-stimulating protein (ASP), is a pivotal protein in the complement system of the innate immune response. Synthesized primarily in the liver, C3 is secreted into the bloodstream and resides mainly in the extracellular space, which is crucial for its role in immediate defense against pathogens. The extracellular location allows C3 to interact directly with foreign invaders, leading to their opsonization and the activation of the complement cascade. Upon activation, C3 is cleaved into C3a and C3b fragments; C3a acts as an anaphylatoxin mediating inflammatory responses, while C3b binds to pathogen surfaces to enhance phagocytosis by immune cells. Dysregulation of C3 can result in increased susceptibility to infections or autoimmune disorders. Anti-C3 antibody (2898) specifically recognizes the C-terminus of C3a and intact C3 of human origin and is recommended for use in western blotting (WB) and immunoprecipitation (IP). By targeting a key region of C3, anti-C3 antibody (2898) is an invaluable tool for studying complement activation pathways and their significance in immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C3 Antibody (2898) | sc-52629 | 100 µg/ml | $322.00 |