Molecular structure of C24:1 Ceramide, CAS Number: 54164-50-0
C24:1 Ceramide (CAS 54164-50-0)
Alternate Names:
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-15Z-tetracosenamide
Application:
C24:1 Ceramide is a naturally occurring ceramide
CAS Number:
54164-50-0
Purity:
>98%
Molecular Weight:
648.10
Molecular Formula:
C42H81NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C24:1 Ceramide is a naturally occurring ceramide. Production of ceramide occurs when hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase. Ceramide mediate a lot of different biological activities. It is involved in cell cycle regulation, apoptosis, inflammation, and stress response.
C24:1 Ceramide (CAS 54164-50-0) References
- Interfacial interactions of ceramide with dimyristoylphosphatidylcholine: impact of the N-acyl chain. | Holopainen, JM., et al. 2001. Biophys J. 80: 765-75. PMID: 11159444
- Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | Miguet, C., et al. 2001. Cell Death Differ. 8: 83-99. PMID: 11313706
- Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. | Separovic, D., et al. 2007. Biochem Biophys Res Commun. 358: 196-202. PMID: 17467659
- Ceramide acyl chain length markedly influences miscibility with palmitoyl sphingomyelin in bilayer membranes. | Westerlund, B., et al. 2010. Eur Biophys J. 39: 1117-28. PMID: 19908035
- S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. | Argraves, KM., et al. 2011. Lipids Health Dis. 10: 70. PMID: 21554699
- Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation. | Pinto, SN., et al. 2011. Biochim Biophys Acta. 1808: 2753-60. PMID: 21835161
- Nano-LC-MS/MS for the quantitation of ceramides in mice cerebrospinal fluid using minimal sample volume. | Thomas, D., et al. 2013. Talanta. 116: 912-8. PMID: 24148494
- Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. | Bergman, BC., et al. 2015. Am J Physiol Endocrinol Metab. 309: E398-408. PMID: 26126684
- Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. | Separovic, D., et al. 2017. Anticancer Res. 37: 1213-1218. PMID: 28314284
- Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity. | Maldonado-Hernández, J., et al. 2017. Can J Gastroenterol Hepatol. 2017: 3689375. PMID: 28634575
- Increased de novo ceramide synthesis and accumulation in failing myocardium. | Ji, R., et al. 2017. JCI Insight. 2: PMID: 28724803
- Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells. | Khayrullin, A., et al. 2019. Cells. 8: PMID: 30634626
- Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption. | Kim, BJ., et al. 2019. Aging (Albany NY). 11: 9388-9404. PMID: 31675352
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C24:1 Ceramide, 1 mg | sc-210992A | 1 mg | $57.00 | |||
C24:1 Ceramide, 5 mg | sc-210992 | 5 mg | $176.00 | |||
C24:1 Ceramide, 10 mg | sc-210992B | 10 mg | $322.00 |