Date published: 2025-10-12

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C22 Ceramide (CAS 869501-30-4)

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CAS Number:
869501-30-4
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C22 Ceramide, identified by the CAS number 869501-30-4, is a synthetic analog of naturally occurring ceramides, characterized by its notably long 22-carbon fatty acid chain. This molecular structure distinguishes C22 Ceramide within the family of sphingolipids, which are crucial components of cellular membranes and play pivotal roles in modulating a variety of cellular signaling pathways. In research environments, C22 Ceramide is extensively utilized to study the mechanisms of lipid-mediated signaling that influence cellular homeostasis, apoptosis, and differentiation. The elongated fatty acid chain of C22 Ceramide influences the physical properties of cellular membranes, such as fluidity and phase behavior, which are essential for the proper functioning of membrane-bound proteins and lipid rafts. By incorporating C22 Ceramide into experimental models, scientists are able to explore how variations in lipid chain length affect the organization and stability of lipid rafts, and subsequently, how these changes impact the signaling pathways that control cellular responses to environmental stimuli. Furthermore, C22 Ceramide serves as a critical tool in the field of lipidomics, helping to explain the complex interactions between various lipid species within the cell and their collective role in regulating cellular processes. This research is fundamental for advancing our understanding of cell biology, particularly the complex network of lipid signaling that underpins many aspects of cellular physiology and pathology.


C22 Ceramide (CAS 869501-30-4) References

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  2. Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.  |  Separovic, D., et al. 2013. Int J Oncol. 43: 2064-72. PMID: 24126464
  3. Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis.  |  Stiban, J. and Perera, M. 2015. Biochim Biophys Acta. 1848: 561-7. PMID: 25462172
  4. The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors.  |  Xu, J., et al. 2016. PLoS One. 11: e0148815. PMID: 26863224
  5. Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice.  |  Goldenberg, JR., et al. 2016. J Mol Cell Cardiol. 94: 1-9. PMID: 26995156
  6. Eleven residues determine the acyl chain specificity of ceramide synthases.  |  Tidhar, R., et al. 2018. J Biol Chem. 293: 9912-9921. PMID: 29632068
  7. Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy.  |  Özer, H., et al. 2018. Lipids Health Dis. 17: 269. PMID: 30474555
  8. Identification of novel diagnostic biomarkers in endometrial cancer using targeted metabolomic profiling.  |  Kozar, N., et al. 2021. Adv Med Sci. 66: 46-51. PMID: 33360772
  9. Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation.  |  Ho, QWC., et al. 2022. Int J Mol Sci. 23: PMID: 36077094
  10. New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae.  |  Hattori, T., et al. 1998. J Nat Prod. 61: 823-6. PMID: 9644076

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C22 Ceramide, 5 mg

sc-210990
5 mg
$300.00