Date published: 2026-1-1

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C20 Dihydroceramide (CAS 121459-06-1)

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Alternate Names:
N-Eicosanoylsphinganine
CAS Number:
121459-06-1
Molecular Weight:
596.02
Molecular Formula:
C38H77NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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C20 Dihydroceramide is a naturally occurring fatty acid derivative of sphinganine. It is a key intermediate in the synthesis of sphingolipids, a group of lipids that are important for cellular membrane structure and function. C20 Dihydroceramide is involved in the regulation of numerous physiological processes, including cell signaling, apoptosis, and inflammation. It is known to interact with various proteins, including G-protein coupled receptors, kinases, and phosphatases, as well as other sphingolipids, such as ceramides and sphingomyelins. It has also been shown to be involved in the regulation of cholesterol metabolism, and has been linked to the development of metabolic disorders such as obesity and diabetes.


C20 Dihydroceramide (CAS 121459-06-1) References

  1. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.  |  Riebeling, C., et al. 2003. J Biol Chem. 278: 43452-9. PMID: 12912983
  2. Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.  |  Sridevi, P., et al. 2010. Exp Cell Res. 316: 78-91. PMID: 19800881
  3. Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis.  |  Parisi, LR., et al. 2017. Cell Chem Biol. 24: 1445-1454.e8. PMID: 29033315
  4. Metabolomic analysis of white and yellow seminal plasma in turkeys (Meleagris gallopavo).  |  Slowinska, M., et al. 2018. Poult Sci. 97: 1059-1065. PMID: 29272520
  5. Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis.  |  Shin, KO., et al. 2020. Cells. 9: PMID: 32164386
  6. Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.  |  Kim, JL., et al. 2022. J Biol Chem. 298: 101735. PMID: 35181339
  7. Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2α.  |  Xia, QS., et al. 2022. Biomed Pharmacother. 150: 112955. PMID: 35429745
  8. Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation.  |  Ho, QWC., et al. 2022. Int J Mol Sci. 23: PMID: 36077094
  9. Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease.  |  Richardson, WJ., et al. 2024. Mol Pharmacol. 105: 131-143. PMID: 38164625

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C20 Dihydroceramide, 5 mg

sc-210989
5 mg
$333.00

C20 Dihydroceramide, 10 mg

sc-210989A
10 mg
$510.00