Molecular structure of C20 Ceramide, CAS Number: 7344-02-7
C20 Ceramide (CAS 7344-02-7)
Alternate Names:
N-Arachidoyl-D-sphingosine
CAS Number:
7344-02-7
Purity:
≥98%
Molecular Weight:
594.01
Molecular Formula:
C38H75NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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C20 Ceramide is a long-chain ceramide that is frequently studied in the field of biochemistry and cell biology. This lipid molecule is a critical component in the study of sphingolipid metabolism, which plays a significant role in cell membrane structure and signaling. Researchers use C20 Ceramide to understand the mechanisms of cell signaling pathways that involve sphingolipids, such as apoptosis, proliferation, and differentiation. The compound is also utilized in the investigation of ceramide′s role in the formation of lipid rafts, which are specialized membrane domains implicated in the organization of signaling molecules. Moreover, C20 Ceramide is used as a standard in mass spectrometry for the quantification of naturally occurring ceramides within cells and tissues.
C20 Ceramide (CAS 7344-02-7) References
- Differential effects of ceramide species on exocytosis in rat PC12 cells. | Tang, N., et al. 2007. Exp Brain Res. 183: 241-7. PMID: 17624518
- (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | Min, J., et al. 2007. Mol Cancer Res. 5: 801-12. PMID: 17699106
- Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. | Wang, G., et al. 2008. Glia. 56: 449-56. PMID: 18205190
- Autophagy: The missing link between non-enzymatically glycated proteins inducing apoptosis and premature senescence of endothelial cells? | Patschan, S. and Goligorsky, MS. 2008. Autophagy. 4: 521-3. PMID: 18367870
- Torpor induction in mammals: recent discoveries fueling new ideas. | Melvin, RG. and Andrews, MT. 2009. Trends Endocrinol Metab. 20: 490-8. PMID: 19864159
- Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. | Antoon, JW., et al. 2010. Endocrinology. 151: 5124-35. PMID: 20861237
- siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy. | Separovic, D., et al. 2012. Anticancer Res. 32: 2479-2485. PMID: 22753704
- Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. | van Doorn, R., et al. 2012. Acta Neuropathol. 124: 397-410. PMID: 22810490
- The effect of altered sphingolipid acyl chain length on various disease models. | Park, WJ. and Park, JW. 2015. Biol Chem. 396: 693-705. PMID: 25720066
- Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. | Martínez, L., et al. 2015. Oncotarget. 6: 41479-96. PMID: 26539645
- Promotion of hair growth by newly synthesized ceramide mimetic compound. | Park, BM., et al. 2017. Biochem Biophys Res Commun. 491: 173-177. PMID: 28711498
- Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation. | Mücke, VT., et al. 2018. Int J Mol Sci. 19: PMID: 29587453
- Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region- and ceramide species-specific way in male mice. | Zoicas, I., et al. 2020. Addict Biol. 25: e12847. PMID: 31828921
- N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation. | Shin, KO., et al. 2021. Int J Mol Sci. 22: PMID: 34361066
- Genetic Variants Associated with Elevated Plasma Ceramides in Individuals with Metabolic Syndrome. | Lee, S., et al. 2022. Genes (Basel). 13: PMID: 36011408
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C20 Ceramide, 5 mg | sc-214643 | 5 mg | $94.00 |