Molecular structure of C16 Ceramide (N-Palmitoylsphingosine, D-erythro), CAS Number: 24696-26-2
C16 Ceramide (N-Palmitoylsphingosine, D-erythro) (CAS 24696-26-2)
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Alternate Names:
N-Palmitoyl-D-erythro-sphingosine;N-Hexadecanoyl-D-erythro-sphingosine;N-Palmitoyl ceramide
Application:
C16 Ceramide (N-Palmitoylsphingosine, D-erythro) is an endogenous ceramide
CAS Number:
24696-26-2
Purity:
98%
Molecular Weight:
537.9
Molecular Formula:
C34H67NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C16 Ceramide (N-Palmitoylsphingosine, D-erythro) is an abundant, hydrophobic molecular species of endogenous ceramide. It has been found to stimulate ceramide-activated protein kinase, inducing phosphorylation epidermal growth factor. It has also been found to activate NF-kappaB and PKCzeta3.
C16 Ceramide (N-Palmitoylsphingosine, D-erythro) (CAS 24696-26-2) References
- Mass spectrometric identification of increased C16 ceramide levels during apoptosis. | Thomas, RL., et al. 1999. J Biol Chem. 274: 30580-8. PMID: 10521441
- C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. | Eto, M., et al. 2003. Prostate. 57: 66-79. PMID: 12886525
- Ceramide stimulates a cytosolic protein phosphatase. | Dobrowsky, RT. and Hannun, YA. 1992. J Biol Chem. 267: 5048-51. PMID: 1312082
- Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | Osawa, Y., et al. 2005. J Biol Chem. 280: 27879-87. PMID: 15946935
- Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells. | Eto, M., et al. 2006. Int J Urol. 13: 148-56. PMID: 16563140
- Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. | Mathias, S., et al. 1991. Proc Natl Acad Sci U S A. 88: 10009-13. PMID: 1946418
- Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. | Goldschmidt-Arzi, M., et al. 2011. J Struct Biol. 175: 21-30. PMID: 21473916
- C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | Aflaki, E., et al. 2012. Cell Death Dis. 3: e280. PMID: 22419109
- Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation. | Alsahli, A., et al. 2016. Calcif Tissue Int. 98: 511-9. PMID: 26758875
- Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | Grammatikos, G., et al. 2016. Oncotarget. 7: 18095-105. PMID: 26933996
- Total synthesis of stereospecific sphingosine and ceramide. | Shoyama, Y., et al. 1978. J Lipid Res. 19: 250-9. PMID: 632688
- PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. | Müller, G., et al. 1995. EMBO J. 14: 1961-9. PMID: 7744003
- Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. | Lozano, J., et al. 1994. J Biol Chem. 269: 19200-2. PMID: 8034680
Activator of:
NF kappa B, p105, and PPP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C16 Ceramide (N-Palmitoylsphingosine, D-erythro), 5 mg | sc-201379 | 5 mg | $119.00 | |||
C16 Ceramide (N-Palmitoylsphingosine, D-erythro), 25 mg | sc-201379A | 25 mg | $489.00 |