Molecular structure of C12E8, CAS Number: 3055-98-9
C12E8 (CAS 3055-98-9)
Alternate Names:
Dodecyl octaethylene glycol ether; Octaethyleneglycol Mono-n-dodecyl Ether
Application:
C12E8 is a non-ionic detergent used for solubilization of membrane-bound proteins
CAS Number:
3055-98-9
Purity:
≥95%
Molecular Weight:
538.75
Molecular Formula:
C28H58O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C12E8 is a non-ionic detergent useful for solubilization of membrane-bound proteins in their native state, aids in the purification of membrane proteins as a detergent, and assists in the preparation of liposomes by acting as an emulsifier. By forming a surface film on cell surfaces, this compound reduces surface tension and enhances the solubility of hydrophobic molecules. Furthermore, it binds to cell surfaces, contributing to the stabilization of cell membranes and preventing cell damage.
C12E8 (CAS 3055-98-9) References
- Solubilization of Na,K-ATPase from rabbit kidney outer medulla using only C12E8. | Santos, HL., et al. 2002. Braz J Med Biol Res. 35: 277-88. PMID: 11887205
- Shape transformation of giant phospholipid vesicles at high concentrations of C12E8. | Mavcic, B., et al. 2004. Bioelectrochemistry. 63: 183-7. PMID: 15110270
- Resistance of human erythrocyte membranes to Triton X-100 and C12E8. | Crepaldi Domingues, C., et al. 2009. J Membr Biol. 227: 39-48. PMID: 19067023
- Solubilization, purification, and reconstitution of alpha 2 beta 1 isozyme of Na+/K+ -ATPase from caveolae of pulmonary smooth muscle plasma membrane: comparative studies with DHPC, C12E8, and Triton X-100. | Ghosh, B., et al. 2009. Mol Cell Biochem. 323: 169-84. PMID: 19101784
- Effect of the detergent C12E8 on the binding of monoclonal antibodies to the (Ca2(+)-Mg2+)-ATPase of rabbit skeletal sarcoplasmic reticulum. | Mata, AM., et al. 1990. Biochem Soc Trans. 18: 603. PMID: 2148918
- Glutaraldehyde crosslinking analysis of the C12E8 solubilized H,K-ATPase. | Rabon, EC., et al. 1990. Biochim Biophys Acta. 1039: 277-89. PMID: 2165816
- Temperature-dependencies of various catalytic activities of membrane-bound Na+/K+-ATPase from ox brain, ox kidney and shark rectal gland and of C12E8-solubilized shark Na+/K+-ATPase. | Esmann, M. and Skou, JC. 1988. Biochim Biophys Acta. 944: 344-50. PMID: 2846060
- Stability of [3H]ouabain binding to the (Na+ + K+)-ATPase solubilized with C12E8. | Inaba, M. and Maede, Y. 1985. Biochim Biophys Acta. 818: 267-70. PMID: 2992592
- Monomeric and trimeric structures of active Na,K-ATPase in C12E8 solution. | Nakao, T., et al. 1983. Biochem Biophys Res Commun. 113: 361-7. PMID: 6305357
- Kinetic properties of C12E8-solubilized (Na+ + K+)-ATPase. | Esmann, M. and Skou, JC. 1984. Biochim Biophys Acta. 787: 71-80. PMID: 6326841
- Stages of the bilayer-micelle transition in the system phosphatidylcholine-C12E8 as studied by deuterium- and phosphorous-NMR, light scattering, and calorimetry. | Otten, D., et al. 1995. Biophys J. 68: 584-97. PMID: 7696511
- Phospholamban-dependent effects of C12E8 on calcium transport and molecular dynamics in cardiac sarcoplasmic reticulum. | Shi, Y., et al. 1996. Biochemistry. 35: 13393-9. PMID: 8873607
- Ultracentrifugation studies on the transmembrane domain of the human erythrocyte anion transporter band 3 in the detergent C12E8. | Cölfen, H., et al. 1998. Eur Biophys J. 27: 651-5. PMID: 9791945
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C12E8, 500 mg | sc-280634A | 500 mg | $159.00 | |||
C12E8, 1 g | sc-280634 | 1 g | $236.00 |