Src Antibody (17AT28): sc-130124

c-Src Antibody (17AT28) is a mouse monoclonal antibody raised against full-length recombinant human c-Src, a crucial member of the Src family kinases involved in cellular signal transduction. c-Src mouse monoclonal antibody (17AT28) recognizes an epitope within the c-Src immunogen sequence and demonstrates broad species cross-reactivity, detecting Src family kinases in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. The Src family comprises nine members in vertebrates, including c-Src, c-Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. These kinases share conserved structural features: an amino-terminal membrane anchor followed by SH3 and SH2 domains, which facilitate protein-protein interactions and signal transduction. c-Src, also known as pp60Src or proto-oncogene tyrosine-protein kinase Src, undergoes post-translational lipid modifications that anchor c-Src to the inner surface of the plasma membrane. This specific subcellular localization positions c-Src optimally for interaction with cell surface receptors and adhesion molecules, enabling c-Src to transmit signals that regulate cellular processes including proliferation, differentiation, motility, and adhesion. When c-Src becomes misregulated or aberrantly activated, the resulting dysregulation can promote uncontrolled cell growth and contribute to cancer progression. Anti-c-Src monoclonal antibody (17AT28) serves as an invaluable tool for researchers investigating signal transduction pathways, cellular growth regulation, and oncogenic processes.

The preferred Src antibody is Src Antibody (B-12): sc-8056.