c-Maf Antibody (6B8): sc-293420

c-Maf Antibody (6B8) is a mouse monoclonal IgG2b kappa light chain antibody engineered to detect c-Maf, a vital member of the Maf family of basic leucine zipper (bZIP) transcription factors. c-Maf monoclonal antibody (6B8) targets amino acids 304-403 of the human c-Maf protein, ensuring precise recognition of c-Maf across mouse, rat, and human species, and is compatible with applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog, c-Maf plays a critical role in regulating gene expression during essential biological processes including hematopoiesis, embryonic lens fiber cell development, T-cell apoptosis, and chondrocyte terminal differentiation. By modulating transcription in both positive and negative directions depending on interacting partners and promoter contexts, c-Maf influences a wide range of developmental and physiological functions. c-Maf interacts with key proteins like c-Myb and Ets-1 to facilitate early myeloid cell differentiation and binds to T-MARE sites to regulate target genes. anti-c-Maf antibody (6B8) is available in a non-conjugated form, offering flexibility for various experimental needs. c-Maf (6B8) antibody is an indispensable tool for researchers exploring the multifaceted roles of c-Maf in cellular differentiation, oncogenesis, and transcriptional regulation. Whether investigating the molecular mechanisms underlying hematopoietic lineage commitment or studying lens development, c-Maf monoclonal antibody (6B8) provides reliable and accurate detection of this proto-oncogene across multiple experimental platforms.

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c-Maf Antibody (6B8) References:

1. Regulation of mouse lens fiber cell development and differentiation by the Maf gene.  |  Ring, BZ., et al. 2000. Development. 127: 307-17. PMID: 10603348
2. MafA has strong cell transforming ability but is a weak transactivator.  |  Nishizawa, M., et al. 2003. Oncogene. 22: 7882-90. PMID: 12970735
3. Expression of c-maf and mafB genes in the skin during rat embryonic development.  |  Ogata, A., et al. 2004. Acta Histochem. 106: 65-7. PMID: 15032330
4. Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver.  |  Imaki, J., et al. 2004. Biochem Biophys Res Commun. 320: 1323-7. PMID: 15249232
5. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.  |  Xu, M., et al. 2018. Nature. 554: 373-377. PMID: 29414937
6. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10.  |  Brockmann, L., et al. 2023. Immunity. 56: 2719-2735.e7. PMID: 38039966
7. Rab GDP dissociation inhibitor: putting rab GTPases in the right place.  |  Pfeffer, SR., et al. 1995. J Biol Chem. 270: 17057-9. PMID: 7615494
8. Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentiation.  |  Igarashi, K., et al. 1995. Proc Natl Acad Sci U S A. 92: 7445-9. PMID: 7638211
9. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.  |  Kataoka, K., et al. 1995. Mol Cell Biol. 15: 2180-90. PMID: 7891713
10. Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.  |  Johnsen, O., et al. 1996. Nucleic Acids Res. 24: 4289-97. PMID: 8932385
11. c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.  |  Hedge, SP., et al. 1998. Mol Cell Biol. 18: 2729-37. PMID: 9566892
12. Rat maf-related factors: the specificities of DNA binding and heterodimer formation.  |  Matsushima-Hibiya, Y., et al. 1998. Biochem Biophys Res Commun. 245: 412-8. PMID: 9571165

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Maf Antibody (6B8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Maf Antibody (6B8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Maf Antibody (6B8) Specifications

Alternate Product Name: MAF bZIP transcription factor

Product Clone Name: 6B8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 304-403

Epitope Target: c-Maf

Epitope Species: human

Product Reactivity/Detection: c-Maf

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for c-Maf Antibody (6B8): N/A

The preferred c-Maf antibody is c-Maf Antibody (E-7): sc-518062.