c-Kit Antibody (3C11): sc-53147

c-Kit Antibody (3C11) is a rat monoclonal IgG2b antibody developed to target c-Kit, a critical receptor tyrosine kinase, in mouse samples using flow cytometry (FCM). The c-Kit protein, also known as CD117, is a transmembrane protein that plays a pivotal role in various cellular processes, including chemotaxis, cell proliferation, apoptosis, and adhesion. Anti-c-Kit antibody (3C11) is raised against IL-3-dependent mast cells derived from normal bone marrow, ensuring precise recognition and binding to the native form of c-Kit in these cells. c-Kit interacts with several key proteins to mediate functions, including stem cell factor (SCF), which is its primary ligand, initiating downstream signaling pathways essential for hematopoiesis and mast cell development. Additionally, c-Kit interacts with intracellular signaling molecules such as PI3K, Akt, and the MAPK/ERK pathway components, which are crucial for transmitting signals that regulate cell survival, growth, and differentiation. These interactions are vital for maintaining normal cellular functions and tissue homeostasis. Disruptions in c-Kit interactions, often due to mutations or aberrant signaling, are implicated in the pathogenesis and progression of various cancers, including gastrointestinal stromal tumors (GISTs) and certain leukemias, making c-Kit a significant target for therapeutic interventions. Anti-c-Kit antibody (3C11) effectively binds to c-Kit on mouse cells, facilitating accurate detection and analysis of c-Kit expression and its interactions with other proteins. This makes anti-c-Kit antibody (3C11) an invaluable tool for researchers studying the molecular mechanisms of c-Kit signaling, its role in disease development, and the potential for targeted cancer therapies.

The preferred c-Kit antibody is c-Kit Antibody (E-3): sc-365504.