c-Kit Antibody (2B8): sc-19619

c-Kit Antibody (2B8) is a rat monoclonal IgG2b antibody engineered to target the c-Kit protein, a vital receptor tyrosine kinase that plays a crucial role in various cellular processes including chemotaxis, cell proliferation, apoptosis, and adhesion. The c-Kit protein, also known as CD117, is essential for the development and function of mast cells and hematopoietic stem cells, making c-Kit indispensable for normal hematopoiesis and immune responses. The importance of c-Kit extends to its involvement in oncogenic processes, where mutations and dysregulation of c-Kit are linked to the growth and progression of several cancers, such as gastrointestinal stromal tumors and certain leukemias. Understanding and targeting c-Kit is therefore critical for both basic biological research and the development of targeted cancer therapies. c-Kit monoclonal antibody (2B8) is raised against bone marrow mast cells of mouse origin and demonstrates robust reactivity in both mouse and rat species when utilized in immunofluorescence (IF) and flow cytometry (FCM) applications. Anti-c-Kit monoclonal antibody (2B8) serves as a valuable tool for researchers investigating the mechanisms of hematopoiesis, mast cell biology, and oncogenesis, as well as for those developing and testing new therapeutic strategies aimed at c-Kit related pathways.

The preferred c-Kit antibody is c-Kit Antibody (E-3): sc-365504.