C-6 NBD-dihydro-Ceramide CAS: 114301-95-0
MF: C30H51N5O6
MW: 577.8
A biologically active fluorescent probe.

C-6 NBD-dihydro-Ceramide (CAS 114301-95-0)

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Alternate Names: N-C6-NBD-D-erythro-dihydro-Sphingosine
Application: C-6 NBD-dihydro-Ceramide is a biologically active fluorescent probe
CAS Number: 114301-95-0
Molecular Weight: 577.8
Molecular Formula: C30H51N5O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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C-6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides. It is as effective as C-6 ceramide in the inhibition of viral glycoprotein transport through the Golgi.1 C-6 NBD ceramide has been used as a fluorescent substrate for the activity of UDP-glucose:ceramide glucosyltransferase2 and to demonstrate the translocation of glucocerebroside and sphingomyelin from the Golgi to the plasma membrane.3 C-6 NBD-dihydro-Ceramide is structurally indistinguishable to C-6 NBD ceramide, except it contains a saturated bond in the C-4/C-5 position of the sphingosine backbone.


References

1 Rosenwald, A.G., Pagano, R.E. Inhibition of glycoprotein traffic through the secretory pathway by ceramide. J. Biol. Chem. 268 4577-4579 (1993). 2 Paul, P., Kamisaka, Y., Marks, D.L., et al. Purification and characterization of UDP-glucose: Ceramide glucosyltransferase from rat liver Golgi membranes. J Biol Chem 271 2287-2293 (1996). 3 Lipsky, N.G., Pagano, R.E. Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: Endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the golgi apparatus en route to the plasma membrane. J Cell Biol 100 27-34 (1985).

Physical State :
Solid
Storage :
Store at -20° C
Fluoresence :
λex 450 nm, λem 530 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71311691
SMILES :
CCCCCCCCCCCCCCC[[email protected]]([[email protected]](CO)NC(=O)CCCCCNC1=CC=C(C2=NON=C12)[N+](=O)[O-])O

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Certificate of Analysis

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Versand nach Deutschland (Hochschule Emden) möglich? Wie teuer ist der Versand? Wie lange dauert die Lieferung ca?

Asked by: fenja89
Sehr geehrte Frau Stolle, vielen Dank für Ihr Interesse an unserem Produkt. Wir haben einen Europäischen Sitz und ein Lager in Heidelberg. Der Versand wird auf Dry Ice erfolgen und kostet 20 Euro. Bitte kontaktieren Sie uns per Telefon: 06221 45 03 0 oder per Email: [email protected] Wir freuen uns auf Sie! Viele Grüße
Answered by: Technical Support Europe
Date published: 2017-03-24
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