C-12 NBD-dihydro-Ceramide (CAS 474943-05-0)

C-12 NBD-dihydro-Ceramide is a fluorescently labeled derivative of dihydroceramide, a key intermediate in sphingolipid metabolism. Its mechanism of action involves mimicking endogenous dihydroceramide, thereby allowing for the visualization and quantification of dihydroceramide dynamics within cells. As a research tool, C-12 NBD-dihydro-Ceramide has been instrumental in studying sphingolipid biology, including the role of dihydroceramide in cellular processes such as apoptosis, autophagy, and cell signaling. By fluorescently labeling dihydroceramide, researchers can track its subcellular localization and metabolism in real-time using live-cell imaging techniques. Additionally, C-12 NBD-dihydro-Ceramide has been employed to investigate the impact of dihydroceramide dysregulation on cellular homeostasis and its implications in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Furthermore, this fluorescent probe enables the exploration of dihydroceramide-mediated signaling pathways and their crosstalk with other lipid species and cellular components. Through its precise labeling and versatile applications, C-12 NBD-dihydro-Ceramide continues to advance our understanding of sphingolipid metabolism and its role in health and disease.