BzATP triethylammonium salt (CAS 112898-15-4)
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BzATP triethylammonium salt functions primarily as a potent agonist of the P2X7 receptor, demonstrating a notably higher efficacy in receptor activation compared to ATP, suggesting it to be between five to ten times more potent. This enhanced potency makes BzATP useful in the study of P2X7 receptor dynamics and its role in cellular signaling. Beyond its primary action, BzATP has partial agonist activity at other purinergic receptor sites, such as P2X1 and P2Y1 receptors, with a reported pEC50 value of 8.7 at P2X1 receptors. This capability to interact with multiple receptor types adds a layer of complexity to its utility in purinergic signaling research. BzATP has been utilized in biochemical studies as a photoaffinity label for ATPase enzymes, aiding in the elucidation of binding sites and mechanistic insights into ATPase function and regulation. This multifaceted application across different receptor interactions and enzyme studies underlines its importance in molecular and cellular biology research, particularly in the exploration of ATP-mediated processes and signaling pathways.
BzATP triethylammonium salt (CAS 112898-15-4) References
- Smoking enhances the proinflammatory effects of nucleotides on cytokine release from human lung. | Belchamber, K., et al. 2014. PLoS One. 9: e99711. PMID: 24978193
- Caveolin-1 regulates P2X7 receptor signaling in osteoblasts. | Gangadharan, V., et al. 2015. Am J Physiol Cell Physiol. 308: C41-50. PMID: 25318104
- P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation. | Jiang, T., et al. 2015. Neurobiol Aging. 36: 2304-2318. PMID: 25983062
- Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. | Karmakar, M., et al. 2016. Nat Commun. 7: 10555. PMID: 26877061
- Biphasic Effect of ATP on In Vitro Mineralization of Dental Pulp Cells. | Techatharatip, O., et al. 2018. J Cell Biochem. 119: 488-498. PMID: 28598038
- Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity. | Wang, F., et al. 2018. EBioMedicine. 30: 303-316. PMID: 29463472
- A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis. | Sasaki, S., et al. 2018. Kidney Blood Press Res. 43: 1409-1424. PMID: 30212831
- MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice. | Li, XQ., et al. 2019. Brain Behav Immun. 79: 91-101. PMID: 31100367
- HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. | Datta, G., et al. 2019. Front Cell Neurosci. 13: 329. PMID: 31379513
- Protective Effects of Hydrogen Sulfide Against the ATP-Induced Meningeal Nociception. | Koroleva, K., et al. 2020. Front Cell Neurosci. 14: 266. PMID: 32982692
- ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors. | Hørlyck, S., et al. 2021. Am J Physiol Heart Circ Physiol. 320: H699-H712. PMID: 33306443
- P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation. | Dunning, K., et al. 2021. Int J Mol Sci. 22: PMID: 34207150
- The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. | Cai, X., et al. 2021. Int Immunopharmacol. 101: 108297. PMID: 34717202
- HMGB1-NLRP3-P2X7R pathway participates in PM2.5-induced hippocampal neuron impairment by regulating microglia activation. | Liu, C., et al. 2022. Ecotoxicol Environ Saf. 239: 113664. PMID: 35605331
- Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. | Williams, N. and Coleman, PS. 1982. J Biol Chem. 257: 2834-41. PMID: 6460764
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BzATP triethylammonium salt, 5 mg | sc-203862 | 5 mg | $153.00 |