Molecular structure of BYK204165, CAS Number: 1104546-89-5
BYK204165 (CAS 1104546-89-5)
See product citations (2)
Alternate Names:
PARP Inhibitor XIV; 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
Application:
BYK204165 is a potent and selective PARP-1 inhibitior
CAS Number:
1104546-89-5
Purity:
≥98%
Molecular Weight:
252.27
Molecular Formula:
C15H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BYK204165, also known as PARP Inhibitor XIV, is a cell-permeable isoquinolinedione compound that potently and selectively inhibits PARP-1 (poly (ADP-ribose) polymerase 1). PARP1 is a nuclear enzyme involved in the regulation of various cell processes such as differentiation, proliferation, and tumor transformation. It is also involved in the regulation of the molecular events involved in the recovery of cell from DNA damage. BYK204165′s potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2.
BYK204165 (CAS 1104546-89-5) References
- Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. | Eltze, T., et al. 2008. Mol Pharmacol. 74: 1587-98. PMID: 18809672
- Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. | Ma, W., et al. 2012. Proc Natl Acad Sci U S A. 109: 6590-5. PMID: 22493268
- Cytotoxic effects of fascaplysin against small cell lung cancer cell lines. | Hamilton, G. 2014. Mar Drugs. 12: 1377-89. PMID: 24608973
- MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation. | Chen, H., et al. 2014. Nat Struct Mol Biol. 21: 981-9. PMID: 25306110
- Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma. | Hallett, RM., et al. 2016. Mol Oncol. 10: 1461-1472. PMID: 27599694
- PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. | Luo, X., et al. 2017. Mol Cell. 65: 260-271. PMID: 28107648
- Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. | Papp, E., et al. 2018. Cell Rep. 25: 2617-2633. PMID: 30485824
- Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. | Bolderson, E., et al. 2019. Nat Commun. 10: 5501. PMID: 31796734
- Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods. | Hu, H., et al. 2020. PeerJ. 8: e9241. PMID: 32509471
- Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. | Huang, D., et al. 2020. Mol Cell. 79: 934-949.e14. PMID: 32822587
- Combinatorial Treatment with PARP-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth through Fos-Driven Changes in Gene Expression. | Gupte, R., et al. 2022. Mol Cancer Res. 20: 1183-1192. PMID: 35503086
- Multiomics analysis of the NAD+-PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells. | Jones, A. and Kraus, WL. 2022. Genes Dev. 36: 601-617. PMID: 35654456
- Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism. | Nakamura, H., et al. 2022. J Biol Chem. 298: 102137. PMID: 35714766
- PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response. | Tan, A., et al. 2023. Cell Death Discov. 9: 133. PMID: 37087471
Inhibitor of:
PARP, and PARP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BYK204165, 5 mg | sc-214642 | 5 mg | $106.00 | |||
BYK204165, 25 mg | sc-214642A | 25 mg | $437.00 |