Molecular structure of BX 513 hydrochloride, CAS Number: 193542-65-3
BX 513 hydrochloride (CAS 193542-65-3)
Alternate Names:
4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
CAS Number:
193542-65-3
Purity:
≥99%
Molecular Weight:
481.46
Molecular Formula:
C28H29ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). A full inverse agonist at US28, a HCMV-encoded chemokine receptor.
BX 513 hydrochloride (CAS 193542-65-3) References
Hesselgesser et al (1998) Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 273 15687. Ng et al (1999) Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 42 4680. Casarosa et al (2003) Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 278 5172.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BX 513 hydrochloride, 10 mg | sc-203861 | 10 mg | $195.00 | |||
| US: Only available in the US | ||||||
BX 513 hydrochloride, 50 mg | sc-203861A | 50 mg | $825.00 | |||
| US: Only available in the US | ||||||