Molecular structure of BW A868C, CAS Number: 118675-50-6
BW A868C (CAS 118675-50-6)
Alternate Names:
3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid
Application:
BW A868C is a hydantoin compound structurally related to the DP agonist BW245C
CAS Number:
118675-50-6
Purity:
>98%
Molecular Weight:
459.58
Molecular Formula:
C25H37N3O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BW A868C is used in research to study its effects on cellular signaling pathways, particularly those involving adenosine receptors. This compound is instrumental in exploring the modulation of adenosine receptor activity, which plays a role in various physiological processes such as inflammation, neurotransmission, and immune responses. Researchers utilize BW A868C to delve into the specific interactions and regulatory mechanisms that adenosine receptors have on cellular functions. In addition, BW A868C is used to investigate the potential of adenosine receptor modulation in influencing cellular responses under different physiological and pathological conditions.
BW A868C (CAS 118675-50-6) References
- Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. | Rahman, A., et al. 2007. Eur J Pharmacol. 554: 229-34. PMID: 17112500
- Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. | Arai, I., et al. 2007. Eur J Pharmacol. 556: 207-14. PMID: 17141215
- Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin. | Alvarez, R., et al. 1991. Prostaglandins. 42: 105-19. PMID: 1775633
- The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | Hamid-Bloomfield, S., et al. 1990. Br J Pharmacol. 100: 761-6. PMID: 2119842
- The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | Trist, DG., et al. 1989. Br J Pharmacol. 96: 301-6. PMID: 2466517
- Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. | Hamid-Bloomfield, S. and Whittle, BJ. 1989. Br J Pharmacol. 96: 307-12. PMID: 2647205
- The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | Giles, H., et al. 1989. Br J Pharmacol. 96: 291-300. PMID: 2924081
- Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? | Rangachari, PK., et al. 1995. J Pharmacol Exp Ther. 275: 611-7. PMID: 7473146
- PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | Warren, JB., et al. 1994. Am J Physiol. 266: H1846-53. PMID: 7515584
- Further studies on ocular responses to DP receptor stimulation. | Woodward, DF., et al. 1993. Eur J Pharmacol. 230: 327-33. PMID: 8440310
- Effects of BW A868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations. | Liu, YJ., et al. 1996. Eur J Pharmacol. 303: 187-92. PMID: 8813566
- Partial agonist effects of BW A868C, a selective DP receptor antagonist, on Cl- secretion in dog tracheal epithelium. | Liu, YJ., et al. 1996. Eur J Pharmacol. 304: 117-22. PMID: 8813592
- Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. | Minami, T., et al. 1996. J Pharmacol Exp Ther. 278: 1146-52. PMID: 8819497
- Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | Lydford, SJ., et al. 1996. Prostaglandins. 52: 125-39. PMID: 8880898
Inhibitor of:
DP.Activator of:
PGD2 synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BW A868C, 1 mg | sc-204660 | 1 mg | $143.00 | |||
BW A868C, 10 mg | sc-204660A | 10 mg | $1142.00 |