Molecular structure of BW 723C86 hydrochloride, CAS Number: 160521-72-2
BW 723C86 hydrochloride (CAS 160521-72-2)
Alternate Names:
α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine, monohydrochloride
Application:
BW 723C86 hydrochloride is a SR-2B agonist
CAS Number:
160521-72-2
Purity:
>98%
Molecular Weight:
322.85
Molecular Formula:
C16H18N2OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BW 723C86 hydrochloride is a research chemical with notable specificity as a 5-HT2B receptor agonist. This selectivity makes it useful in neurological research, particularly in the study of serotonin receptor function and its role in the central nervous system. Researchers utilize BW 723C86 hydrochloride to investigate the behavioral and physiological effects mediated by 5-HT2B receptor activation. The compound is also instrumental in cardiovascular research, as 5-HT2B receptors have been implicated in heart valve function and the development of cardiac fibrosis, providing a model for studying pathophysiological processes.
BW 723C86 hydrochloride (CAS 160521-72-2) References
- Vasodilator and vasoconstrictor responses induced by 5-hydroxytryptamine in the in situ blood autoperfused hindquarters of the anaesthetized rat. | Calama, E., et al. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 110-6. PMID: 12122496
- Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety. | Nic Dhonnchadha, BA., et al. 2003. Behav Brain Res. 140: 203-14. PMID: 12644293
- Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. | McCreary, AC., et al. 2003. Behav Neurosci. 117: 212-21. PMID: 12708517
- Implication of 5-HT2A subtype receptors in DOI activity in the four-plates test-retest paradigm in mice. | Ripoll, N., et al. 2006. Behav Brain Res. 166: 131-9. PMID: 16154212
- Anxiolytic-like effect of 5-HT(2) ligands and benzodiazepines co-administration: comparison of two animal models of anxiety (the four-plate test and the elevated plus maze). | Massé, F., et al. 2007. Behav Brain Res. 177: 214-26. PMID: 17175036
- Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. | Bourin, M. and Hascoët, M. 2010. Behav Brain Res. 208: 352-8. PMID: 20006646
- Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. | Aira, Z., et al. 2013. Pain. 154: 1865-1877. PMID: 23769718
- Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA. | Perim, RR., et al. 2018. Am J Physiol Regul Integr Comp Physiol. 314: R709-R715. PMID: 29384698
- Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. | Snider, MA., et al. 2018. J Anim Sci. 96: 1570-1578. PMID: 29471490
- Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit. | Iovino, L., et al. 2019. Brain Res. 1704: 26-39. PMID: 30244021
- Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. | Kennett, GA., et al. 1996. Br J Pharmacol. 117: 1443-8. PMID: 8730737
- BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. | Kennett, GA., et al. 1997. Neuropharmacology. 36: 233-9. PMID: 9144661
- Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. | Duxon, MS., et al. 1997. Neuropharmacology. 36: 601-8. PMID: 9225285
- Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. | Kennett, GA., et al. 1998. Neuropharmacology. 37: 1603-10. PMID: 9886683
Activator of:
SR-2B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BW 723C86 hydrochloride, 10 mg | sc-203428 | 10 mg | $169.00 | |||
BW 723C86 hydrochloride, 50 mg | sc-203428A | 50 mg | $688.00 |