Molecular structure of BW 245C, CAS Number: 72814-32-5
BW 245C (CAS 72814-32-5)
Alternate Names:
(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid
Application:
BW 245C is a DP agonist
CAS Number:
72814-32-5
Molecular Weight:
368.47
Molecular Formula:
C19H32N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective agonist for the DP1 receptor, 1,2 where the Ki for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM.1 This compound has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation3 and an IC50 of 250 nM for the inhibition of rat platelet aggregation.2
BW 245C (CAS 72814-32-5) References
- Characterization of prostanoid receptors mediating inhibition of histamine release from anti-IgE-activated rat peritoneal mast cells. | Chan, CL., et al. 2000. Br J Pharmacol. 129: 589-97. PMID: 10711359
- Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. | Ajuebor, MN., et al. 2000. Am J Physiol Gastrointest Liver Physiol. 279: G238-44. PMID: 10898767
- Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways. | Halm, DR. and Halm, ST. 2001. Am J Physiol Gastrointest Liver Physiol. 281: G984-96. PMID: 11557519
- Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. | Shiraishi, Y., et al. 2005. J Pharmacol Exp Ther. 312: 954-60. PMID: 15528449
- Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. | Gallant, MA., et al. 2005. J Bone Miner Res. 20: 672-81. PMID: 15765187
- The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | Hamid-Bloomfield, S., et al. 1990. Br J Pharmacol. 100: 761-6. PMID: 2119842
- Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. | Featherstone, RL., et al. 1990. Naunyn Schmiedebergs Arch Pharmacol. 341: 439-43. PMID: 2142256
- The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | Giles, H., et al. 1989. Br J Pharmacol. 96: 291-300. PMID: 2924081
- Effect of prostacyclin (PGI2) and a prostaglandin analogue BW 245C on galactosamine-induced hepatic necrosis. | Noda, Y., et al. 1986. J Hepatol. 2: 53-64. PMID: 3512686
- Behavioural, ECoG spectrum power and body temperature effects of BW 245C, a prostaglandin analogue after intraventricular microinjection in chicks. | Rotiroti, D., et al. 1981. Neuropharmacology. 20: 517-20. PMID: 7242872
- Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? | Rangachari, PK., et al. 1995. J Pharmacol Exp Ther. 275: 611-7. PMID: 7473146
- Functional characterization of the prostanoid DP receptor in human myometrium. | Fernandes, B. and Crankshaw, D. 1995. Eur J Pharmacol. 283: 73-81. PMID: 7498323
- Intraocular pressure effects of selective prostanoid receptor agonists involve different receptor subtypes according to radioligand binding studies. | Woodward, DF., et al. 1993. J Lipid Mediat. 6: 545-53. PMID: 8358015
- Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery. | Baxter, GS., et al. 1995. Br J Pharmacol. 116: 1692-6. PMID: 8564239
Activator of:
DP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BW 245C, 1 mg | sc-205230 | 1 mg | $103.00 | |||
BW 245C, 5 mg | sc-205230A | 5 mg | $370.00 |