Molecular structure of BVT 948, CAS Number: 39674-97-0
BVT 948 (CAS 39674-97-0)
See product citations (2)
Alternate Names:
4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
Application:
BVT 948 is a non-competitive protein tyrosine phosphatase inhibitor
CAS Number:
39674-97-0
Purity:
≥98%
Molecular Weight:
241.25
Molecular Formula:
C14H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor. This compound enhances insulin signalling and insulin tolerance in ob/ob mice. BVT 948 displays irreversible inhibition via catalysis of hydrogen peroxide-dependent oxidation of PTP. BVT 948 is an inhibitor of CYP.
BVT 948 (CAS 39674-97-0) References
- Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. | Liljebris, C., et al. 2004. J Pharmacol Exp Ther. 309: 711-9. PMID: 14747616
- Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. | Haskew-Layton, RE., et al. 2010. Proc Natl Acad Sci U S A. 107: 17385-90. PMID: 20855618
- Characterization of in vivo keratin 19 phosphorylation on tyrosine-391. | Zhou, Q., et al. 2010. PLoS One. 5: e13538. PMID: 21049038
- Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ. | Pendleton, JC., et al. 2013. Exp Neurol. 247: 113-21. PMID: 23588220
- Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α. | Poirier, V., et al. 2014. J Biol Chem. 289: 29376-85. PMID: 25187516
- Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. | Kiris, E., et al. 2015. PLoS One. 10: e0129264. PMID: 26061731
- Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives. | Yu, CH., et al. 2018. Biosci Rep. 38: PMID: 29540535
- Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. | Wang, L., et al. 2018. Cell Rep. 23: 3091-3101. PMID: 29874593
- Synthesis and biological evaluation of (3'-amino-[1,1'-biphenyl]-4-yl) sulfamic acid derivatives as novel HPTPβ inhibitors. | Zhang, W., et al. 2018. Bioorg Chem. 81: 270-277. PMID: 30165257
- The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells. | Choi, DK., et al. 2020. Sci Rep. 10: 12089. PMID: 32694555
- High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity. | Choi, R., et al. 2021. PLoS One. 16: e0250019. PMID: 33886614
- Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. | Misek, SA., et al. 2022. Mol Pharmacol. 101: 1-12. PMID: 34732527
- Phosphatase inhibitors BVT-948 and alexidine dihydrochloride inhibit sexual development of the malaria parasite Plasmodium berghei. | Jia, X., et al. 2022. Int J Parasitol Drugs Drug Resist. 19: 81-88. PMID: 35792443
Inhibitor of:
CYP, DEP-1, Protein tyrosine phosphatase receptor (PTPR), PTP, PTP 1β, PTPψ, and PTPRCAP.Activator of:
TC-PTP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BVT 948, 10 mg | sc-203536 | 10 mg | $163.00 | |||
BVT 948, 50 mg | sc-203536A | 50 mg | $663.00 |