Butenoyl PAF
Molecular Weight:
549.7
Molecular Formula:
C28H56NO7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Butenoyl and butanoyl PAF are products of the oxidative decomposition of 2-arachidonoyl phospholipids.1 Oxygenation of C-5 of the 5,6 double bond followed by cleavage of the hydroperoxide creates a PAF-like compound with a 4-carbon residue esterified in the sn-2 position; similar oxidized lipid products also act as ligands for oxidized lipid receptors and peroxisome proliferator-activated receptor.2 Butenoyl PAF is less potent than PAF as a PAF receptor agonist, it is present in amounts 100-fold greater than enzymatically generated PAF. Therefore, oxidation of LDL phospholipids generates physiologically relevant bioactive PAF-like molecules.
Butenoyl PAF References
1 Marathe, G.K., Davies, S.S., Harrison, K.A., et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem 274 28395-28404 (1999). 2 Davies, S.S., Pontsler, A.V., Marathe, G.K., et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists. J Biol Chem 276 16015-16023 (2001).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butenoyl PAF, 1 mg | sc-221388 | 1 mg | $84.00 | |||
Butenoyl PAF, 5 mg | sc-221388A | 5 mg | $379.00 |