Molecular structure of Butaprost, free acid, CAS Number: 433219-55-7
Butaprost, free acid (CAS 433219-55-7)
Application:
Butaprost, free acid is a selective EP2 agonist
CAS Number:
433219-55-7
Molecular Weight:
394.6
Molecular Formula:
C23H38O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Butaprost is an EP2 selective agonist that has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells (1,2). Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400, whereas butaprost, free acid exhibits a significantly lower Ki value of 73 nM (3). Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.
Butaprost, free acid (CAS 433219-55-7) References
- Restoring metabolism of myeloid cells reverses cognitive decline in ageing. | Minhas, PS., et al. 2021. Nature. 590: 122-128. PMID: 33473210
- Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation. | Wang, W., et al. 2022. J Immunol. 208: 1912-1923. PMID: 35379745
- Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma. | Hou, R., et al. 2022. Cell Rep. 39: 111000. PMID: 35732130
- KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis. | Penke, LR., et al. 2022. JCI Insight. 7: PMID: 35852857
- Human Amniotic Membrane Mesenchymal Stem Cell-Synthesized PGE2 Exerts an Immunomodulatory Effect on Neutrophil Extracellular Trap in a PAD-4-Dependent Pathway through EP2 and EP4. | Estúa-Acosta, GA., et al. 2022. Cells. 11: PMID: 36139406
- Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling? | Hou, R., et al. 2022. Biomed Pharmacother. 156: 113966. PMID: 36411643
- PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression. | Zhao, Y., et al. 2023. EMBO Mol Med. 15: e16373. PMID: 36511116
- Downregulation of COL12A1 and COL13A1 by a selective EP2 receptor agonist, omidenepag, in human trabecular meshwork cells. | Kumon, M., et al. 2023. PLoS One. 18: e0280331. PMID: 36630412
- Prostaglandin E2-Transporting Pathway and Its Roles via EP2/EP4 in Cultured Human Dental Pulp. | Ohkura, N., et al. 2023. J Endod.. PMID: 36758673
Activator of:
EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butaprost, free acid, 500 µg | sc-223847 | 500 µg | $148.00 | |||
Butaprost, free acid, 1 mg | sc-223847A | 1 mg | $281.00 |