Date published: 2026-4-19

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Butabindide oxalate (CAS 185213-03-0)

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Application:
Butabindide oxalate is a selective and potent inhibitor of tripeptidyl peptidase II.
CAS Number:
185213-03-0
Purity:
≥98%
Molecular Weight:
393.44
Molecular Formula:
C17H25N3O2•C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Butabindide oxalate is a selective and potent inhibitor of TPPII (tripeptidyl peptidase II). TPP II is an enzyme involved in the breakdown of proteins, specifically targeting tripeptides for cleavage, which plays a part in the broader system of protein degradation and turnover within cells. By inhibiting TPP II, butabindide oxalate can influence protein processing and degradation pathways, shedding light on the complex mechanisms of intracellular protein regulation. This compound′s selective inhibition of TPP II makes it valuable in biochemical research, particularly in studies aiming to dissect the role of protein degradation in cellular physiology and the maintenance of cellular homeostasis.


Butabindide oxalate (CAS 185213-03-0) References

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  2. A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.  |  Reits, E., et al. 2004. Immunity. 20: 495-506. PMID: 15084277
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  6. Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire.  |  Oliveira, CC., et al. 2014. Mol Immunol. 62: 129-36. PMID: 24983205
  7. Dual proteolytic pathways govern glycolysis and immune competence.  |  Lu, W., et al. 2014. Cell. 159: 1578-90. PMID: 25525876
  8. Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells.  |  Baleeiro, RB., et al. 2015. Oncoimmunology. 4: e1047585. PMID: 26985398
  9. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.  |  Lirussi, D., et al. 2017. EBioMedicine. 22: 100-111. PMID: 28754303
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Butabindide oxalate, 10 mg

sc-361130
10 mg
$189.00

Butabindide oxalate, 50 mg

sc-361130A
50 mg
$770.00