Busulfan-d8 (CAS 116653-28-2)
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Busulfan-d8, a deuterated derivative of busulfan, is utilized in scientific studies due to its stable isotopic labeling, which significantly enhances the precision of pharmacokinetic and metabolic profiling. The presence of eight deuterium atoms in its structure makes it an ideal candidate for mass spectrometry and NMR spectroscopy, allowing researchers to track its metabolic pathways and interactions with biomolecules with greater accuracy and less isotopic effect than its non-deuterated counterpart. This specificity is particularly valuable in studies aiming to understand the complex mechanisms underlying its alkylating properties, where it forms cross-links within DNA, thereby disrupting DNA replication and cell division. As such, busulfan-d8 serves as a critical tool in molecular biology research, contributing to the elucidation of cellular processes and the development of novel research methodologies.
Busulfan-d8 (CAS 116653-28-2) References
- High-performance liquid chromatographic method for quantification of busulfan in plasma after derivatization by tetrafluorothiophenol. | Quernin, MH., et al. 1999. J Chromatogr B Biomed Sci Appl. 721: 147-52. PMID: 10027646
- Quantification of busulfan in plasma using liquid chromatography electrospray tandem mass spectrometry (HPLC-ESI-MS/MS). | Snyder, ML. and Ritchie, JC. 2010. Methods Mol Biol. 603: 129-36. PMID: 20077065
- Monolithic packed 96-tips set for high-throughput sample preparation: determination of cyclophosphamide and busulfan in whole blood samples by monolithic packed 96-tips and LC-MS. | Skoglund, C., et al. 2013. Biomed Chromatogr. 27: 714-9. PMID: 23225551
- Gas chromatographic-mass spectrometric quantitation of busulfan in human plasma for therapeutic drug monitoring: a new on-line derivatization procedure for the conversion of busulfan to 1,4-diiodobutane. | Athanasiadou, I., et al. 2014. J Pharm Biomed Anal. 90: 207-14. PMID: 24389463
- LC-MS/MS method development for quantification of busulfan in human plasma and its application in pharmacokinetic study. | Nadella, TR., et al. 2016. J Pharm Biomed Anal. 120: 168-74. PMID: 26736033
- Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration. | Matsumoto, K., et al. 2016. Biol Blood Marrow Transplant. 22: 1968-1973. PMID: 27470288
- Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children. | Dilo, A., et al. 2020. Ther Drug Monit. 42: 111-117. PMID: 31348116
- Gas chromatographic-mass spectrometric assay for busulfan in biological fluids using a deuterated internal standard. | Vassal, G., et al. 1988. J Chromatogr. 428: 357-61. PMID: 3215938
- Pharmacokinetic analysis for model-supported therapeutic drug monitoring of busulfan in Japanese pediatric hematopoietic stem cell transplantation recipients. | Kishimoto, K., et al. 2020. Pediatr Transplant. 24: e13696. PMID: 32196880
- Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). | Pablo, A., et al. 2020. Curr Protoc Toxicol. 84: e93. PMID: 32469450
- Fast and reliable quantification of busulfan in blood plasma using two-channel liquid chromatography tandem mass spectrometry: Validation of assay performance in the presence of drug formulation excipients. | Andersen, AM., et al. 2021. J Pharm Biomed Anal. 203: 114216. PMID: 34182411
- Therapeutic Drug Monitoring of Busulfan in Patients Undergoing Hematopoietic Cell Transplantation: A Pilot Single-Center Study in Taiwan. | Chen, RL., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34206798
- Quantification of busulfan in plasma by gas chromatography-mass spectrometry following derivatization with tetrafluorothiophenol. | Quernin, MH., et al. 1998. J Chromatogr B Biomed Sci Appl. 709: 47-56. PMID: 9653925
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Busulfan-d8, 2.5 mg | sc-217804 | 2.5 mg | $398.00 |