Molecular structure of Buspirone hydrochloride, CAS Number: 33386-08-2
Buspirone hydrochloride (CAS 33386-08-2)
Application:
Buspirone hydrochloride is a SR-1A agonist
CAS Number:
33386-08-2
Molecular Weight:
421.97
Molecular Formula:
C21H31N5O2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Buspirone hydrochloride is extensively studied in neuroscientific research for its interaction with neurotransmitter systems, particularly serotonin receptors. This compound is of interest due to its ability to modulate neurotransmitter activity without the typical sedative effects associated with other agents acting on the central nervous system. Research on Buspirone hydrochloride focuses on its binding affinity and efficacy at different serotonin receptor subtypes, which aids in understanding its potential mechanisms of action. Additionally, studies investigate the compound′s effects on neurochemical pathways that influence mood and anxiety. The kinetics of Buspirone hydrochloride, including its absorption, distribution, metabolism, and excretion, are also critical areas of study to understand its behavior and impact in neurological research applications.
Buspirone hydrochloride (CAS 33386-08-2) References
- Development and validation of an in vitro-in vivo correlation for buspirone hydrochloride extended release tablets. | Takka, S., et al. 2003. J Control Release. 88: 147-57. PMID: 12586512
- Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. | Al-Khalili, M., et al. 2003. AAPS PharmSci. 5: E14. PMID: 12866941
- Buspirone hydrochloride in the treatment of an atypical paraphilia. | Fedoroff, JP. 1992. Arch Sex Behav. 21: 401-6. PMID: 1497477
- Efficacy of the 5-HT1A agonist, buspirone hydrochloride, in migraineurs with anxiety: a randomized, prospective, parallel group, double-blind, placebo-controlled study. | Lee, ST., et al. 2005. Headache. 45: 1004-11. PMID: 16109114
- Solid-state characterization of buspirone hydrochloride polymorphs. | Sheikhzadeh, M., et al. 2006. Pharm Res. 23: 1043-50. PMID: 16715396
- Solubility analysis of buspirone hydrochloride polymorphs: measurements and prediction. | Sheikhzadeh, M., et al. 2007. Int J Pharm. 338: 55-63. PMID: 17317053
- Brain targeting studies on buspirone hydrochloride after intranasal administration of mucoadhesive formulation in rats. | Khan, S., et al. 2009. J Pharm Pharmacol. 61: 669-75. PMID: 19406007
- The discovery and development of buspirone: a new approach to the treatment of anxiety. | New, JS. 1990. Med Res Rev. 10: 283-326. PMID: 2196403
- Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. | Bshara, H., et al. 2014. Carbohydr Polym. 99: 297-305. PMID: 24274510
- Lyophilized sustained release mucoadhesive chitosan sponges for buccal buspirone hydrochloride delivery: formulation and in vitro evaluation. | Kassem, MA., et al. 2015. AAPS PharmSciTech. 16: 537-47. PMID: 25370025
- Brain delivery of buspirone hydrochloride chitosan nanoparticles for the treatment of general anxiety disorder. | Bari, NK., et al. 2015. Int J Biol Macromol. 81: 49-59. PMID: 26210037
- Formulation and Evaluation of Niosomal in situ Nasal Gel of a Serotonin Receptor Agonist, Buspirone Hydrochloride for the Brain Delivery via Intranasal Route. | Mathure, D., et al. 2018. Pharm Nanotechnol. 6: 69-78. PMID: 29380709
- Buspirone Hydrochloride Loaded In Situ Nanovesicular Gel as an Anxiolytic Nasal Drug Delivery System: In Vitro and Animal Studies. | Abdelnabi, DM., et al. 2019. AAPS PharmSciTech. 20: 134. PMID: 30830481
- Response Surface Methodology for Optimization of Buspirone Hydrochloride-Loaded In Situ Gel for Pediatric Anxiety. | Abdallah, MH., et al. 2022. Gels. 8: PMID: 35877480
- Buspirone hydrochloride: a unique new anxiolytic agent. Pharmacokinetics, clinical pharmacology, abuse potential and clinical efficacy. | Goldberg, HL. 1984. Pharmacotherapy. 4: 315-24. PMID: 6151170
Inhibitor of:
Serotonin.Activator of:
Prolactin, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Buspirone hydrochloride, 1 g | sc-202982 | 1 g | $92.00 |