Molecular structure of Buspirone, CAS Number: 36505-84-7
Buspirone (CAS 36505-84-7)
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Alternate Names:
Buspin; 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Application:
Buspirone is 5-hydroxytryptamine (5-HT1) receptor agonist
CAS Number:
36505-84-7
Molecular Weight:
385.5
Molecular Formula:
C21H31N5O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Buspirone is a compound widely studied in the context of its affinity for serotonin receptors, particularly the 5-HT1A receptor. In neuroscientific research, buspirone is utilized to understand the modulation of the serotonergic system and its effects on neurotransmission. It serves as a useful tool in exploring the mechanisms underlying the regulation of mood and anxiety at a molecular level. Additionally, buspirone is of interest in the study of the interaction between serotonergic and dopaminergic systems, as it may act to influence dopamine neurotransmitter pathways. Moreover, the compound is used to assess changes in behavior that result from altered serotonin receptor activity. Research on buspirone also extends to its effects on the hypothalamic-pituitary-adrenal (HPA) axis, which plays a significant role in stress response.
Buspirone (CAS 36505-84-7) References
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- Predictive QSPR study of the dissociation constants of diverse pharmaceutical compounds. | Mercader, AG., et al. 2010. Chem Biol Drug Des. 76: 433-40. PMID: 20925694
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- Anti-Migraine Effect of the Herbal Combination of Chuanxiong Rhizoma and Cyperi Rhizoma and UPLC-MS/MS Method for the Simultaneous Quantification of the Active Constituents in Rat Serum and Cerebral Cortex. | Wu, S., et al. 2019. Molecules. 24: PMID: 31207980
- Identification and quantification of the quality markers and anti-migraine active components in Chuanxiong Rhizoma and Cyperi Rhizoma herbal pair based on chemometric analysis between chemical constituents and pharmacological effects. | Guo, L., et al. 2020. J Ethnopharmacol. 246: 112228. PMID: 31513838
- Wide-scope target screening of >2000 emerging contaminants in wastewater samples with UPLC-Q-ToF-HRMS/MS and smart evaluation of its performance through the validation of 195 selected representative analytes. | Gago-Ferrero, P., et al. 2020. J Hazard Mater. 387: 121712. PMID: 31784138
- Combination of different chromatographic and sampling modes for high-resolution mass spectrometric screening of organic microcontaminants in water. | Castro, V., et al. 2021. Anal Bioanal Chem. 413: 5607-5618. PMID: 33625537
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- Suppression of opiate withdrawal and cocaine hyperarousal syndromes by buspirone. Possible pharmacotherapeutic applications. | Aceto, MD. and Bowman, ER. 1993. Arzneimittelforschung. 43: 942-5. PMID: 8240454
Inhibitor of:
SR-1A.Activator of:
Serotonin, SR-3A, and SR-5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Buspirone, 2.5 g | sc-504347 | 2.5 g | $301.00 |