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Buserelin (CAS 57982-77-1)

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Alternate Names:
(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH
CAS Number:
57982-77-1
Molecular Weight:
1239.42
Molecular Formula:
C60H86N16O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Buserelin is a peptide that functions as a gonadotropin-releasing hormone (GnRH) agonist. It acts by binding to and activating GnRH receptors in the pituitary gland, leading to the initial release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continued administration, buserelin desensitizes the pituitary gland, ultimately leading to decreased secretion of LH and FSH. This results in a reduction in the production of sex hormones such as testosterone and estrogen. At the molecular level, buserelin′s interaction with GnRH receptors inhibits the synthesis and secretion of gonadotropins, thereby disrupting the normal hormonal feedback loop. This disruption ultimately suppresses the function of the gonads, which may be useful for studying the regulation of reproductive hormones and related physiological processes.


Buserelin (CAS 57982-77-1) References

  1. The mechanisms of antitumor effects of luteinizing hormone-releasing hormone agonist (buserelin) in 7, 12-dimethylbenz(a)anthracene-induced rat mammary cancer.  |  Koibuchi, Y., et al. 1999. Int J Mol Med. 4: 145-8. PMID: 10402480
  2. The effect of the gonadotropin-releasing hormone analog, buserelin, on pregnancy rates in horse and pony mares.  |  Newcombe, JR., et al. 2001. Theriogenology. 55: 1619-31. PMID: 11393215
  3. Recovery rate and recovery time in cows with luteal and follicular ovarian cysts after treatment with buserelin.  |  Veronesi, MC., et al. 2003. Vet Res Commun. 27 Suppl 1: 631-3. PMID: 14535484
  4. Influence of an agonist of gonadotropin-releasing hormone (buserelin) on estrus synchronization and fertility in beef cows.  |  Twagiramungu, H., et al. 1992. J Anim Sci. 70: 1904-10. PMID: 1634414
  5. Use of buserelin acetate in an in vitro fertilization program: a comparison with classical clomiphene citrate-human menopausal gonadotropin treatment.  |  Lejeune, B., et al. 1990. Fertil Steril. 54: 475-81. PMID: 2118860
  6. Testicular fluid content evaluated by ultrasound image computer-assisted analysis increases with small-dose multiple GnRH injections in rams.  |  Ungerfeld, R. and Fila, D. 2011. Reprod Domest Anim. 46: 720-3. PMID: 21198970
  7. Cytogenetic analysis of unfertilized oocytes retrieved after treatment with the LHRH analogue, buserelin.  |  Delhanty, JD. and Penketh, RJ. 1990. Hum Reprod. 5: 699-702. PMID: 2123883
  8. Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling.  |  D'Hondt, M., et al. 2014. Int J Pharm. 467: 48-9. PMID: 24657556
  9. Protection of GnRH analogue by chitosan-dextran sulfate nanoparticles for intravaginal application in rabbit artificial insemination.  |  Casares-Crespo, L., et al. 2018. Theriogenology. 116: 49-52. PMID: 29777964
  10. Improvement of in vitro fertilisation after treatment with buserelin, an agonist of luteinising hormone releasing hormone.  |  Rutherford, AJ., et al. 1988. Br Med J (Clin Res Ed). 296: 1765-8. PMID: 3136830
  11. The antiandrogen anandron potentiates the castrating effect of the LH-RH agonist buserelin in the rat.  |  Moguilewsky, M. and Tournemine, C. 1988. Am J Clin Oncol. 11 Suppl 2: S148-51. PMID: 3149454
  12. Effects of buserelin administration on testicular blood flow and plasma concentrations of testosterone and estradiol-17β in rams.  |  El-Shalofy, AS. and Hedia, MG. 2021. Domest Anim Endocrinol. 77: 106646. PMID: 34175682
  13. In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs.  |  Hoogstraate, AJ., et al. 1996. Pharm Res. 13: 1233-7. PMID: 8865318

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Buserelin, 1 mg

sc-353114
1 mg
$190.00

Buserelin, 5 mg

sc-353114A
5 mg
$746.00