Bumetanide β-D-Glucuronide (CAS 102623-14-3)

Bumetanide β-D-Glucuronide is a glucuronide conjugate of bumetanide, formed through the phase II metabolism process known as glucuronidation, a crucial pathway for enhancing the solubility of hydrophobic molecules and facilitating their removal from the body. This compound is extensively used in scientific research to understand the metabolic pathways of small molecules, particularly how they are processed and eliminated in biological systems. The β-D-glucuronide group attached to bumetanide increases the molecule′s hydrophilicity, which is essential for the excretion of metabolites via renal or biliary routes. In research contexts, Bumetanide β-D-Glucuronide serves as a critical tool for studying the activity of the enzyme UDP-glucuronosyltransferase, which catalyzes the glucuronidation process. Insights gained from such studies are vital for the development of biochemical assays that assess enzyme efficiency and the interaction of xenobiotics with metabolic pathways. Additionally, understanding the behavior of glucuronide conjugates like Bumetanide β-D-Glucuronide helps in the environmental sciences, where researchers evaluate the fate and transport of biologically active compounds in aquatic systems, thus aiding in ecological risk assessments and the development of strategies to mitigate environmental exposure to such molecules.