Date published: 2025-12-17

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Buflomedil hydrochloride (CAS 35543-24-9)

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Alternate Names:
4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
Application:
Buflomedil hydrochloride is a neurotransmitter agent
CAS Number:
35543-24-9
Purity:
>98%
Molecular Weight:
343.85
Molecular Formula:
C17H25NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Buflomedil hydrochloride is a compound that functions as a vasodilator by inhibiting phosphodiesterase activity, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This increase in cAMP levels results in relaxation of smooth muscle cells in blood vessels, leading to vasodilation. By targeting phosphodiesterase activity, buflomedil hydrochloride modulates the cellular signaling pathways involved in vascular tone regulation. Buflomedil hydrochloride′s mode of action involves its interaction with phosphodiesterase enzymes, which are responsible for the degradation of cAMP. By inhibiting these enzymes, buflomedil hydrochloride effectively increases cAMP levels, leading to vasodilation and improved blood flow. This mechanism of action makes buflomedil hydrochloride a relevant compound for studying the regulation of vascular tone and its potential implications in experimental.


Buflomedil hydrochloride (CAS 35543-24-9) References

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  2. Protective effect of buflomedil in a rat model of moderate cerebral ischemia.  |  Briguglio, FS., et al. 2005. Arzneimittelforschung. 55: 437-42. PMID: 16149710
  3. Gas chromatographic-mass spectrometric analysis of buflomedil hydrochloride in biological samples after acute intoxication.  |  De Giovanni, N. and Fucci, N. 1991. Forensic Sci Int. 51: 125-9. PMID: 1752588
  4. Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.  |  Kaity, S., et al. 2013. Carbohydr Polym. 94: 456-67. PMID: 23544563
  5. Preparation and evaluation of a buflomedil hydrochloride niosomal patch for transdermal delivery.  |  Akhtar, N., et al. 2015. J Liposome Res. 25: 191-201. PMID: 25357198
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  8. Controlled simultaneous iontophoresis of buflomedil hydrochloride and dexamethasone sodium phosphate to the mucosa for oral submucous fibrosis.  |  Tyagi, V., et al. 2021. Int J Pharm. 607: 121009. PMID: 34391856
  9. Effects of buflomedil hydrochloride in occlusive arterial disease of the lower limbs stage IV.  |  Briguglio, F., et al. 1986. J Int Med Res. 14: 115-23. PMID: 3721052
  10. Determination of buflomedil hydrochloride [2',4',6'-trimethoxy-4-(pyrrolidinyl)butyrophenone hydrochloride] by reversed-phase ion-pair high-performance liquid chromatography.  |  Badmin, JA., et al. 1979. J Chromatogr. 172: 319-25. PMID: 548535
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  12. Buflomedil hydrochloride attenuates tourniquet-induced microvascular reperfusion injury in striated muscle.  |  Menger, MD., et al. 1994. Int J Microcirc Clin Exp. 14: 296-302. PMID: 7705991
  13. Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia.  |  Holzer, K., et al. 1998. Shock. 10: 335-42. PMID: 9840648

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Buflomedil hydrochloride, 1 g

sc-234225
1 g
$36.00