Date published: 2026-4-5

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Bucetin (CAS 1083-57-4)

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Alternate Names:
N-(4-ethoxyphenyl)-3-hydroxybutanamide
Application:
Bucetin is an antipyretic and analgesic drug that is chemically similar to phenacetin.
CAS Number:
1083-57-4
Molecular Weight:
223.27
Molecular Formula:
C12H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bucetin, traditionally recognized for its application in various research applications, operates primarily through its mechanism of inhibiting the enzyme cyclooxygenase (COX), a key player in the biosynthesis of prostaglandins. Prostaglandins are lipid compounds that perform roles in inflammation and pain signaling pathways, thus making Bucetin a focal point in studies related to inflammatory processes. The inhibition of COX by Bucetin leads to a decrease in the production of prostaglandins, offering a unique avenue for exploring the molecular underpinnings of inflammation. This action is of particular interest in the realm of biochemical and pharmacological research, where understanding the modulation of inflammatory responses at the molecular level can provide insights into the development of novel therapeutic strategies. In research applications, Bucetin serves as a tool to dissect the complex interplay between enzymatic activity and the regulation of physiological processes, contributing to a deeper understanding of cellular and molecular mechanisms underlying inflammation.


Bucetin (CAS 1083-57-4) References

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  2. Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.  |  Honda, GS., et al. 2019. PLoS One. 14: e0217564. PMID: 31136631
  3. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization.  |  Wambaugh, JF., et al. 2019. Toxicol Sci. 172: 235-251. PMID: 31532498
  4. Relationship Between the Gut Microbiome and Systemic Chemotherapy.  |  Ervin, SM., et al. 2020. Dig Dis Sci. 65: 874-884. PMID: 32026181
  5. Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov.  |  Zhang, H., et al. 2020. Interdiscip Sci. 12: 368-376. PMID: 32488835
  6. Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo.  |  Popiolek, M., et al. 2020. Front Mol Neurosci. 13: 568641. PMID: 33192294
  7. Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice.  |  Togei, K., et al. 1987. J Natl Cancer Inst. 79: 1151-8. PMID: 3479641
  8. Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules.  |  You, S., et al. 2022. Chem Sci. 13: 2310-2316. PMID: 35310496
  9. In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions.  |  Martin, P., et al. 2022. Pharmacol Res Perspect. 10: e00959. PMID: 35599347
  10. RAID: Regression Analysis-Based Inductive DNA Microarray for Precise Read-Across.  |  Amano, Y., et al. 2022. Front Pharmacol. 13: 879907. PMID: 35935858
  11. Rare but serious risks associated with non-narcotic analgesics: clinical experience.  |  Kewitz, H. 1986. Med Toxicol. 1 Suppl 1: 86-92. PMID: 3821433
  12. Mechanism of metabolic activation of the analgetic bucetin to bacterial mutagens by hamster liver microsomes.  |  Nohmi, T., et al. 1985. Chem Pharm Bull (Tokyo). 33: 2877-85. PMID: 4085048
  13. Studies on combination dosing (III). Aspirin and ethenzamide.  |  Kawano, O., et al. 1978. Jpn J Pharmacol. 28: 829-35. PMID: 745307
  14. Reappraisal of eight representative carcinogenic and non-carcinogenic compounds in a new medium-term rat liver bioassay using D-galactosamine.  |  Kim, HC., et al. 1996. Cancer Lett. 104: 85-90. PMID: 8640751

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bucetin, 10 g

sc-223846
10 g
$46.00