BU 224 hydrochloride (CAS 187173-05-3)
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BU 224 hydrochloride is a compound that functions as a selective and potent antagonist of the neuropeptide Y (NPY) Y1 receptor. It acts by binding to the Y1 receptor and blocking the binding of NPY, thereby inhibiting the downstream signaling pathways activated by NPY. This interference with NPY signaling may have implications in various physiological processes, including appetite regulation, stress response, and cardiovascular function. By targeting the Y1 receptor, BU 224 hydrochloride can be used to investigate the role of NPY signaling in these processes. In experimental applications, BU 224 hydrochloride is used for studying the physiological and pathophysiological roles of NPY signaling.
BU 224 hydrochloride (CAS 187173-05-3) References
- Novel selective compounds for the investigation of imidazoline receptors. | Hudson, AL., et al. 1999. Ann N Y Acad Sci. 881: 81-91. PMID: 10415900
- Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain. | Robinson, ES., et al. 2002. Eur J Pharmacol. 450: 55-60. PMID: 12176109
- Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. | Finn, DP., et al. 2003. Psychopharmacology (Berl). 167: 195-202. PMID: 12652345
- The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review. | Liaquat, Z., et al. 2021. Brain Sci. 11: PMID: 34202110
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BU 224 hydrochloride, 10 mg | sc-203857 | 10 mg | $119.00 | |||
BU 224 hydrochloride, 50 mg | sc-203857A | 50 mg | $495.00 |