Bu-1b Antibody (5K94): sc-70449
- Bu-1b Antibody (5K94) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against bursal cells from 2- to 5-week-old CHA (Bu1b) strain avians
- recommended for detection of Bu-1b of avian origin by IP, IF and FCM; non cross-reactive with cells from CHA and H.B15Ab strains
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bu-1b Antibody (5K94). This work is in progress.
Bu-1b Antibody (5K94) is a mouse monoclonal IgG1 antibody that detects Bu-1b in avian species through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Bu-1b is a genetically polymorphic cell surface antigen that plays a crucial role in the regulation of cell death, particularly during the development of B lymphocytes. Bu-1b (5K94) antibody recognizes a type I transmembrane glycoprotein, which is essential for maintaining the balance between cell survival and apoptosis in the immune system. Bu-1b expression on B cells and a subset of macrophages indicates involvement in immune responses, as Bu-1b helps to eliminate nonfunctional or self-reactive lymphocytes, thereby preventing autoimmune reactions. Bu-1b is expressed in embryonic spleen and bone marrow cells, marking these tissues as precursors for B cell development. Bu-1b′s ability to induce a rapid form of cell death similar to apoptosis underscores its importance in ensuring that only functional immune cells are allowed to mature and participate in immune responses. The two allelic forms of the Bu-1 gene, Bu-1a and Bu-1b, represent the recessive and dominant products, respectively, further highlighting the genetic diversity and functional implications of this antigen in avian immunology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bu-1b Antibody (5K94) References:
- Vanadium(V) complexes of a chelating dianionic [ONNO]-type amine bis(phenolate) ligand: synthesis and solid state and solution structures. | Wolff, F., et al. 2003. Inorg Chem. 42: 7839-45. PMID: 14632499
- (Fluoren-9-ylidene)methanedithiolato complexes of gold: synthesis, luminescence, and charge-transfer adducts. | Vicente, J., et al. 2004. Inorg Chem. 43: 7516-31. PMID: 15530103
- Macrocyclic and lantern complexes of palladium(II) with bis(amidopyridine) ligands: synthesis, structure, and host-guest chemistry. | Yue, NL., et al. 2004. Inorg Chem. 43: 7671-81. PMID: 15554632
- Early separation of B and T lymphocyte precursors in chick embryo. | Houssaint, E., et al. 1991. J Exp Med. 174: 397-406. PMID: 1856628
- Identification and characterization of two distinct bursal B-cell subpopulations following infectious bursal disease virus infection of White Leghorn chickens. | Petkov, DI., et al. 2009. Avian Dis. 53: 347-55. PMID: 19848071
- Synthesis and reactivity of diphosphine metal complexes bearing peripheral ketenimine functionalities. | Ruiz, J., et al. 2009. Dalton Trans. 9280-90. PMID: 20449207
- Room temperature and highly enantioselective additions of alkyltitanium reagents to aldehydes catalyzed by a titanium catalyst of (R)-H8-binol. | Li, Q. and Gau, HM. 2011. Chirality. 23: 929-39. PMID: 21953806
- Benzannulated N-heterocyclic germylenes and stannylenes with sterically demanding N,N'-substituents. | Krupski, S., et al. 2014. Dalton Trans. 43: 173-81. PMID: 24121532
- Monoclonal antibodies against chicken Bu-1a and Bu-1b alloantigens. | Veromaa, T., et al. 1988. Hybridoma. 7: 41-8. PMID: 2453446
- Bu-1 antigen expression as a marker for B cell precursors in chicken embryos. | Houssaint, E., et al. 1989. Eur J Immunol. 19: 239-43. PMID: 2649381
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bu-1b Antibody (5K94) | sc-70449 | 100 µg/ml | $322.00 |