Bu-1a Antibody (5K93): sc-70448
- Bu-1a Antibody (5K93) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against bursal cells from one day old H.B15 (Bu-1a/b/b) strain avian
- recommended for detection of Bu-1a on bursal cells, thymocytes, spleen cells and peripheral blood cells of avian origin by IP, IF and FCM; non cross-reactive with cells from CHA and H.B15 strains by immunofluorescence
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bu-1a Antibody (5K93). This work is in progress.
Bu-1a Antibody (5K93) is a mouse monoclonal IgG1 antibody that detects Bu-1 in avian species through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Bu-1 is a genetically polymorphic cell surface antigen that plays a crucial role in the regulation of cell death, particularly during the development of B lymphocytes. This type I transmembrane glycoprotein is essential for maintaining immune homeostasis by ensuring that nonfunctional or self-reactive lymphocytes are effectively removed from the immune repertoire. Bu-1 is expressed not only on B cells but also on a subset of macrophages, highlighting Bu-1′s importance in both adaptive and innate immunity. Additionally, Bu-1 expression on embryonic spleen and bone marrow cells marks these tissues as precursors for B cell development, indicating Bu-1′s role in early immune system formation. Bu-1′s ability to induce a rapid form of cell death akin to apoptosis underscores Bu-1′s significance in controlling cell survival and adhesion during B cell maturation. The two allelic forms, Bu-1a and Bu-1b, represent the recessive and dominant products of the Bu-1 gene, respectively, further illustrating the complexity of immune regulation mediated by Bu-1.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bu-1a Antibody (5K93) | sc-70448 | 100 µg/ml | $316.00 |