Molecular structure of BTZO 1, CAS Number: 99420-15-2
BTZO 1 (CAS 99420-15-2)
Alternate Names:
NSC679036
Application:
BTZO 1 is a binder of the macrophage migration inhibitory factor (MIF)
CAS Number:
99420-15-2
Molecular Weight:
240.28
Molecular Formula:
C13H8N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
BTZO 1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.
BTZO 1 (CAS 99420-15-2) References
- BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression. | Kimura, H., et al. 2010. Chem Biol. 17: 1282-94. PMID: 21168764
- Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. | Mathew, B., et al. 2013. Am J Respir Cell Mol Biol. 49: 269-78. PMID: 23526214
- Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. | Yukitake, H., et al. 2017. Oxid Med Cell Longev. 2017: 8584930. PMID: 28191280
- NRF2 as an Emerging Therapeutic Target. | Copple, IM., et al. 2017. Oxid Med Cell Longev. 2017: 8165458. PMID: 28250892
- Correlations of MIF polymorphism and serum levels of MIF with glucocorticoid sensitivity of sudden sensorineural hearing loss. | Zhu, WY., et al. 2020. J Int Med Res. 48: 300060519893870. PMID: 31889466
- Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma. | Zhang, X., et al. 2020. Oncogene. 39: 4770-4779. PMID: 32366905
- Antioxidant response element activator, BTZO-1, improves the developmental competence of bovine oocytes. | Aboelenain, M., et al. 2020. Reprod Domest Anim. 55: 1021-1024. PMID: 32473610
Inhibitor of:
Apoptosis.Activator of:
Transcription Factor.Substrate of:
MIF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BTZO 1, 5 mg | sc-362720 | 5 mg | $101.00 | |||
BTZO 1, 25 mg | sc-362720A | 25 mg | $398.00 |