BTLA Antibody (4B8): sc-517004

BTLA Antibody (4B8) is a mouse monoclonal IgG2a kappa light chain antibody that detects BTLA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BTLA antibody (4B8) is available as the non-conjugated format. The B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein that plays a crucial role in regulating immune responses, particularly during T-cell activation. BTLA is structurally similar to other coinhibitory receptors such as CTLA-4 and PD-1, which are also part of the CD28 family; however, BTLA uniquely interacts with the herpesvirus entry mediator (HVEM), a TNF receptor, rather than the B7-Ig family of counter receptors. This interaction serves as a molecular switch that modulates T-cell activation by transmitting inhibitory signals through BTLA, thereby maintaining immune homeostasis and preventing excessive immune responses. The conservation of the BTLA-HVEM interaction between mouse and human highlights its significance as a regulatory pathway in lymphocyte activation, making BTLA a vital target for research in immunology and potential therapeutic interventions.

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BTLA Antibody (4B8) References:

1. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.  |  Watanabe, N., et al. 2003. Nat Immunol. 4: 670-9. PMID: 12796776
2. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.  |  Sedy, JR., et al. 2005. Nat Immunol. 6: 90-8. PMID: 15568026
3. A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator.  |  Gonzalez, LC., et al. 2005. Proc Natl Acad Sci U S A. 102: 1116-21. PMID: 15647361
4. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.  |  Cheung, TC., et al. 2005. Proc Natl Acad Sci U S A. 102: 13218-23. PMID: 16131544
5. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts.  |  Tao, R., et al. 2005. J Immunol. 175: 5774-82. PMID: 16237069
6. Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.  |  Krieg, C., et al. 2005. J Immunol. 175: 6420-7. PMID: 16272294

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BTLA Antibody (4B8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BTLA Antibody (4B8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BTLA Antibody (4B8) Specifications

Alternate Product Name: BTLA

Product Clone Name: 4B8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 190-289

Epitope Target: BTLA

Epitope Species: human

Product Reactivity/Detection: BTLA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BTLA Antibody (4B8): N/A