BTG4 Antibody (NB-B3): sc-134287
- BTG4 Antibody (NB-B3) is a mouse monoclonal IgG2b κ BTG4 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant BTG4 protein of human origin
- recommended for detection of BTG4 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BTG4 Antibody (NB-B3). This work is in progress.
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BTG4 Antibody (NB-B3) is a mouse monoclonal IgG2b kappa light chain antibody that detects BTG4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BTG4 antibody (NB-B3) is available as a non-conjugated format. BTG4, also known as PC3B, is a member of the B cell translocation gene family, which includes BTG1-4, and is recognized for its role in regulating transcription and acting as an anti-proliferative factor. This 223 amino acid protein is predominantly expressed in the testis and olfactory epithelium, highlighting its potential significance in reproductive and sensory functions. BTG4 expression is often diminished in primary gastric cancer, suggesting a possible role in tumor suppression, as BTG4 may be epigenetically silenced in many gastric cancer cases. BTG4 has been implicated in chronic lymphocytic leukemia, indicating its relevance in hematological malignancies. The conserved N-terminal domain of BTG4, spanning 104-106 amino acids, is crucial for its function, as BTG4 is involved in interactions with other cellular factors that regulate cell cycle progression and apoptosis.
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BTG4 Antibody (NB-B3) References:
- BTG1, a member of a new family of antiproliferative genes. | Rouault, JP., et al. 1992. EMBO J. 11: 1663-70. PMID: 1373383
- Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. | Auer, RL., et al. 2005. Genes Chromosomes Cancer. 43: 1-10. PMID: 15672409
- Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. | Toyota, M., et al. 2008. Cancer Res. 68: 4123-32. PMID: 18519671
- Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. | Dong, W., et al. 2009. Biochem Biophys Res Commun. 387: 132-8. PMID: 19576178
- Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. | Rouault, JP., et al. 1996. Nat Genet. 14: 482-6. PMID: 8944033
- The mammalian anti-proliferative BTG/Tob protein family. | Winkler, GS. 2010. J Cell Physiol. 222: 66-72. PMID: 19746446
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BTG4 Antibody (NB-B3) | sc-134287 | 100 µg/ml | $339.00 |