Molecular structure of Bryostatin 2, CAS Number: 87745-28-6
Bryostatin 2 (CAS 87745-28-6)
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Application:
Bryostatin 2 is a macrocyclic lactone and antagonist of phorbol ester action
CAS Number:
87745-28-6
Molecular Weight:
863.01
Molecular Formula:
C45H66O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bryostatin 2 is a macrocyclic lactone with anti-tumor properties and activator of PKC (protein kinase C) which inhibit the growth of A549 cells. Bryostatin 2 has been documented to compete with phorbol ester binding to PKC at a Ki= 3.4 nM and antagonizes phorbol esteraction. The compound has been observed to induce variable arachidonic acid release. Bryostatin 2 has demonstrated to synergistically, with recombinant B cell stimulatory factor-1, cause differentiation in resting lymph node T cells. Bryostatin 2 also exhibits growth inhibitory activity against several human cancer cell lines.
Bryostatin 2 (CAS 87745-28-6) References
- Structural modifications of bryostatin 2. | Pettit, GR., et al. 1992. Anticancer Drug Des. 7: 101-14. PMID: 1575884
- Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner. | Bolon, ML., et al. 2007. J Cell Physiol. 211: 159-66. PMID: 17149706
- Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity. | Hornung, RL., et al. 1992. Cancer Res. 52: 101-7. PMID: 1727368
- The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity. | Wender, PA. and Verma, VA. 2008. Org Lett. 10: 3331-4. PMID: 18588309
- Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. | Mackanos, EA., et al. 1991. J Biol Chem. 266: 11205-12. PMID: 1904062
- Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. | Wender, PA., et al. 2011. Proc Natl Acad Sci U S A. 108: 6721-6. PMID: 21415363
- Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. | Jalava, AM., et al. 1990. Cancer Res. 50: 3422-8. PMID: 2334938
- Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex. | Plummer, S., et al. 2016. Bioorg Med Chem Lett. 26: 2489-2497. PMID: 27068183
- Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. | Dale, IL., et al. 1989. Cancer Res. 49: 3242-5. PMID: 2720677
- Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells. | Dale, IL. and Gescher, A. 1989. Int J Cancer. 43: 158-63. PMID: 2910827
- Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. | Dell'Aquila, ML., et al. 1988. Cancer Res. 48: 3702-8. PMID: 3132318
- Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins. | Trenn, G., et al. 1988. J Immunol. 140: 433-9. PMID: 3257237
- Heterogeneity of signal transduction mechanisms in human basophils and human skin mast cells. II. Effects of 7-O-methyl-UCN-01, NPC 15437 and bryostatin 1 and 2, four protein kinase C-modulatory agents, on mediator release. | Noll, T., et al. 1997. Biol Signals. 6: 1-10. PMID: 9098518
Activator of:
PKC, and PSK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bryostatin 2, 10 µg | sc-202086 | 10 µg | $270.00 | |||
Bryostatin 2, 25 µg | sc-202086A | 25 µg | $750.00 |