Molecular structure of Bruton′s Tyrosine Kinase Inhibitor III
Bruton′s Tyrosine Kinase Inhibitor III
Application:
Bruton′s Tyrosine Kinase Inhibitor III is a highly potent, selective, and irreversible inhibitor of BTK
Purity:
≥98%
Molecular Weight:
440.5
Molecular Formula:
C25H24N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bruton′s tyrosine kinase inhibitor III is a cell-permeable pyrrolopyridinyl-acryloyl compound which acts as a highly potent, selective, and irreversible inhibitor of BTK (IC50 = 720 pM) as well as affecting Lyn, Lck, and Itk activity only at much higher concentrations (IC50 = 14 nM, 97 nM, and 1.0 µM, respectively). It inhibits BTK-dependent PLC-phosphorylation and Ca2+ flux in human B cell line, Ramos in vitro (IC50= 14 nM and 40 nM, respectively) and is of excellent efficacy in a murine rheumatoid archritis model.
Bruton′s Tyrosine Kinase Inhibitor III References
- Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. | Pan, Z., et al. 2007. ChemMedChem. 2: 58-61. PMID: 17154430
- Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils. | Krupa, A., et al. 2013. Am J Respir Cell Mol Biol. 48: 240-9. PMID: 23239500
Inhibitor of:
Btk, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bruton′s Tyrosine Kinase Inhibitor III, 1 mg | sc-311301 | 1 mg | $390.00 |