Bromodichloromethane (CAS 75-27-4)
QUICK LINKS
Bromodichloromethane, a non-polar organic solvent, used as a stationary phase in solid phase microextraction (SPME), facilitating the chromatographic analysis of diverse compounds. In addition to its role as a solvent, it exhibits properties as an anti-inflammatory agent and disinfectant. Bromodichloromethane shows inhibitory effects on bacterial growth, including oral pathogens, attributed to its ability to impede the activity of sorbitol dehydrogenase. This action is thought to contribute to its anti-inflammatory properties. Moreover, this compound has been used as a reagent in organic synthesis, as a solvent for chromatography, and as a solvent for extraction. Bromodichloromethane has been used in the synthesis of brominated compounds and in the study of the environmental impact of halogenated hydrocarbons.
Bromodichloromethane (CAS 75-27-4) References
- Pregnancy loss in the rat caused by bromodichloromethane. | Bielmeier, SR., et al. 2001. Toxicol Sci. 59: 309-15. PMID: 11158724
- Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice. | Torti, VR., et al. 2001. Toxicol Sci. 64: 269-80. PMID: 11719710
- Carcinogenicity of bromodichloromethane administered in drinking water to Male F344/N Rats and B6C3F1 mice. | George, MH., et al. 2002. Int J Toxicol. 21: 219-30. PMID: 12055023
- Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane in rat liver. | Allis, JW., et al. 2002. Toxicology. 176: 25-37. PMID: 12062927
- Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. | Chen, J., et al. 2003. Toxicol Sci. 76: 75-82. PMID: 12970577
- Bromodichloromethane inhibits human placental trophoblast differentiation. | Chen, J., et al. 2004. Toxicol Sci. 78: 166-74. PMID: 14691210
- NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in male F344/N rats and female B6C3F1 mice (Drinking Water Studies). | ,. 2006. Natl Toxicol Program Tech Rep Ser. 1-248. PMID: 16741555
- Toxicology studies of bromodichloromethane (CAS No. 75-27-4) in genetically modified (FVB Tg.AC Hemizygous) mice (dermal, drinking water, and gavage studies) and carcinogenicity studies of bromodichloromethane in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water and gavage studies). | ,. 2007. Natl Toxicol Program Genet Modif Model Rep. 1-227. PMID: 18784761
- Bromodichloromethane induces cell proliferation in different tissues of male F344 rats by suppression of E-cadherin expression via hypermethylation or transcriptional activation of c-myc and cyclin D1. | Liao, J., et al. 2013. Toxicol Lett. 223: 162-74. PMID: 24001804
- The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM). | Kenyon, EM., et al. 2016. Toxicol Mech Methods. 26: 620-626. PMID: 27595344
- Low concentrations of bromodichloromethane induce a toxicogenomic response in porcine embryos in vitro. | Pagé-Larivière, F., et al. 2016. Reprod Toxicol. 66: 44-55. PMID: 27671623
- The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM). | Kenyon, EM., et al. 2019. Toxicol Sci. 167: 347-359. PMID: 30252107
- Relationship between Blood Trihalomethane Concentrations and Serum Thyroid Function Measures in U.S. Adults. | Sun, Y., et al. 2021. Environ Sci Technol. 55: 14087-14094. PMID: 34617747
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bromodichloromethane, 10 g | sc-239422 | 10 g | $61.00 | |||
Bromodichloromethane, 50 g | sc-239422A | 50 g | $193.00 |