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Bromoacetyl chloride (CAS 22118-09-8)

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Alternate Names:
2-Bromo-1-chloro-ethanal
Application:
Bromoacetyl chloride is used in the synthesis of α,α-disubstituted thioisomünchnones
CAS Number:
22118-09-8
Purity:
≥95%
Molecular Weight:
157.39
Molecular Formula:
C2H2BrClO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bromoacetyl chloride was used in the synthesis of alpha,alpha-disubstituted thioisomυnchnones. It was also used in the preparation of 1,3-dibromoacetone. It is a diphenyl ether that can be used to detect serine protease in tissue. It also has acylation activity and can be used in the synthesis of β-amino acids.


Bromoacetyl chloride (CAS 22118-09-8) References

  1. Nonadiabatic interactions in wave packet dynamics of the bromoacetyl chloride photodissociation.  |  Lasorne, B., et al. 2004. J Chem Phys. 120: 1271-8. PMID: 15268253
  2. Combined nonadiabatic transition-state theory and ab initio molecular dynamics study on selectivity of the alpha and beta bond fissions in photodissociation of bromoacetyl chloride.  |  Zhang, F., et al. 2006. J Chem Phys. 125: 184305. PMID: 17115750
  3. Nonadiabatic effects in C-Br bond scission in the photodissociation of bromoacetyl chloride.  |  Valero, R. and Truhlar, DG. 2006. J Chem Phys. 125: 194305. PMID: 17129101
  4. Competitive bond rupture in the photodissociation of bromoacetyl chloride and 2- and 3-bromopropionyl chloride: adiabatic versus diabatic dissociation.  |  Hsu, MY., et al. 2013. Chemphyschem. 14: 936-45. PMID: 23400968
  5. Rapid Fluorescent-Based Detection of New Delhi Metallo-β-Lactamases by Photo-Cross-Linking Using Conjugates of Azidonaphthalimide and Zinc(II)-Chelating Motifs.  |  Singha, M., et al. 2019. ACS Omega. 4: 10891-10898. PMID: 31460186
  6. Synthesis of Menthol Glycinates and Their Potential as Cooling Agents.  |  Klumpp, DA., et al. 2020. ACS Omega. 5: 4043-4049. PMID: 32149231
  7. From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.  |  Tomassi, S., et al. 2020. ACS Med Chem Lett. 11: 862-868. PMID: 32435397
  8. Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4.  |  Malebari, AM., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34832901
  9. A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells.  |  Prasad, B., et al. 2022. Chem Sci. 13: 2347-2354. PMID: 35310480
  10. Diels-Alder Adducts of Morphinan-6,8-Dienes and Their Transformations.  |  Marton, J., et al. 2022. Molecules. 27: PMID: 35566212
  11. Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics - synthesis and properties.  |  Stefaniak, J., et al. 2022. J Enzyme Inhib Med Chem. 37: 1928-1956. PMID: 35801410
  12. Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups.  |  Łuczyński, M., et al. 2022. Molecules. 27: PMID: 36431787
  13. N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents.  |  Struga, M., et al. 2023. ACS Omega. 8: 18663-18684. PMID: 37273589

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bromoacetyl chloride, 25 ml

sc-227524
25 ml
$100.00