Molecular structure of Brodimoprim, CAS Number: 56518-41-3
Brodimoprim (CAS 56518-41-3)
Alternate Names:
5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine; 5-(4-Bromo-3,5-dimethoxybenzyl)-2,4-pyrimidinediamine;Hyprim
CAS Number:
56518-41-3
Molecular Weight:
339.19
Molecular Formula:
C13H15BrN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Brodimoprim is an aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group. It has a role as an dihydrofolate reductase inhibitor. Dihydrofolate reductase an enzyme for the synthesis of tetrahydrofolate, which is necessary for the production of nucleic acids and proteins. Brodimoprim is an aminopyrimidine, a member of bromobenzenes and a member of methoxybenzenes. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria. Brodimoprim′s action inhibits the bacterial synthesis of DNA, RNA, and proteins, leading to the inhibition of bacterial growth and replication.
Brodimoprim (CAS 56518-41-3) References
- 1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase. | Morgan, WD., et al. 1999. Biochemistry. 38: 2127-34. PMID: 10026296
- Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). | Seydel, JK., et al. 1983. Chemotherapy. 29: 249-61. PMID: 6347548
- Properties of brodimoprim as an inhibitor of dihydrofolate reductases. | Then, RL. and Hermann, F. 1984. Chemotherapy. 30: 18-25. PMID: 6363003
- Brodimoprim, a new bacterial dihydrofolate reductase inhibitor: a minireview. | Periti, P. 1995. J Chemother. 7: 221-3. PMID: 7562018
- Influence of subinhibitory concentrations of brodimoprim and trimethoprim on the adhesiveness, hydrophobicity, hemagglutination and motility of Escherichia coli. | Braga, PC., et al. 1995. Chemotherapy. 41: 50-8. PMID: 7875023
- Comparative antibacterial spectrum of trimethoprim and brodimoprim. | Amyes, SG. 1993. J Chemother. 5: 417-21. PMID: 8195832
- In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria. | Seydel, JK. 1993. J Chemother. 5: 422-9. PMID: 8195833
- Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria. | Thomson, CJ. 1993. J Chemother. 5: 458-64. PMID: 8195838
- Pharmacokinetics of brodimoprim. | Weidekamm, E. 1993. J Chemother. 5: 475-9. PMID: 8195840
- Pharmacokinetics of brodimoprim in special populations. | Stockis, A., et al. 1993. J Chemother. 5: 480-7. PMID: 8195841
- Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid. | Bergan, T. 1993. J Chemother. 5: 488-9. PMID: 8195842
- Brodimoprim: effects of subminimal inhibitory concentrations on virulence traits of respiratory and urinary tract pathogens, and on plasmid transfer and stability. | Marchese, A., et al. 1996. J Chemother. 8: 171-7. PMID: 8808712
- Brodimoprim synergy against Enterococcus faecalis evaluated in vitro. | Richards, RM. and Xing, JZ. 1996. J Antimicrob Chemother. 38: 27-37. PMID: 8858454
- Penetration of brodimoprim into human neutrophils and intracellular activity. | Braga, PC., et al. 1996. Antimicrob Agents Chemother. 40: 2392-8. PMID: 8891150
- Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils. | Fresta, M., et al. 1996. Antimicrob Agents Chemother. 40: 2865-73. PMID: 9124856
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Brodimoprim, 25 mg | sc-503946 | 25 mg | $388.00 |