Molecular structure of BRL 54443, CAS Number: 57477-39-1
BRL 54443 (CAS 57477-39-1)
Alternate Names:
5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole; 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
Application:
BRL 54443 is a potent agonist at SR-1E and SR-1F
CAS Number:
57477-39-1
Purity:
≥98%
Molecular Weight:
230.31
Molecular Formula:
C14H18N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BRL 54443 is a potent 5-HT1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7, 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E1F, 1A, 1B, 1D, 2A, 2B, 2C, 4, 7, D2 and D3 receptors respectively).
BRL 54443 (CAS 57477-39-1) References
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- Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension. | Watts, SW. 2002. Hypertension. 39: 825-9. PMID: 11897772
- 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. | Dürk, T., et al. 2005. Int Immunol. 17: 599-606. PMID: 15802305
- Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. | Fang, Y., et al. 2007. J Pharmacol Toxicol Methods. 55: 314-22. PMID: 17207642
- Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system. | Filip, M. and Bader, M. 2009. Pharmacol Rep. 61: 761-77. PMID: 19903999
- 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected]. | Machida, T., et al. 2011. Eur J Pharmacol. 656: 19-26. PMID: 21262218
- Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. | Sourbron, J., et al. 2016. ACS Chem Neurosci. 7: 588-98. PMID: 26822114
- 5-HT modulates the rat mesenteric vasopressor outflow by 5-HT1D sympatholytic receptors. | García-Pedraza, JÁ., et al. 2017. Clin Exp Pharmacol Physiol. 44: 1224-1231. PMID: 28771848
- Structural insights into the lipid and ligand regulation of serotonin receptors. | Xu, P., et al. 2021. Nature. 592: 469-473. PMID: 33762731
- Structure of serotonin receptors: molecular underpinning of receptor activation and modulation. | Zweckstetter, M., et al. 2021. Signal Transduct Target Ther. 6: 243. PMID: 34145221
- Molecular Cloning and Functional Characterization of Three 5-HT Receptor Genes (HTR1B, HTR1E, and HTR1F) in Chickens. | Sun, C., et al. 2021. Genes (Basel). 12: PMID: 34207786
Activator of:
GlyR α2, SR-1E, and SR-1F.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRL 54443, 10 mg | sc-203855 | 10 mg | $118.00 | |||
BRL 54443, 50 mg | sc-203855A | 50 mg | $465.00 |