Molecular structure of BRL-50481, CAS Number: 433695-36-4
BRL-50481 (CAS 433695-36-4)
See product citations (2)
Alternate Names:
5-Nitro-2,N,N-trimethylbenzenesulfonamide
Application:
BRL-50481 is a selective inhibitor of PDE 7
CAS Number:
433695-36-4
Purity:
≥98%
Molecular Weight:
244.27
Molecular Formula:
C9H12N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.
BRL-50481 (CAS 433695-36-4) References
- Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. | Smith, SJ., et al. 2004. Mol Pharmacol. 66: 1679-89. PMID: 15371556
- Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts. | Pekkinen, M., et al. 2008. Bone. 43: 84-91. PMID: 18420479
- Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. | Zhang, L., et al. 2008. Proc Natl Acad Sci U S A. 105: 19532-7. PMID: 19033455
- A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors. | Wunder, F., et al. 2009. Mol Pharm. 6: 326-36. PMID: 19049345
- β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. | Zhai, K., et al. 2012. PLoS One. 7: e47826. PMID: 23094097
- Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival. | Medina-Rodríguez, EM., et al. 2013. Cell Mol Life Sci. 70: 3449-62. PMID: 23661015
- PDE4 and PDE5 regulate cyclic nucleotide contents and relaxing effects on carbachol-induced contraction in the bovine abomasum. | Kaneda, T., et al. 2015. J Vet Med Sci. 77: 15-9. PMID: 25319411
- Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. | Sulen, A., et al. 2016. Pharmacol Res. 113: 216-227. PMID: 27543462
- Phosphodiesterase-7 inhibition affects accumbal and hypothalamic thyrotropin-releasing hormone expression, feeding and anxiety behavior of rats. | Valdés-Moreno, MI., et al. 2017. Behav Brain Res. 319: 165-173. PMID: 27864049
- PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure. | Chen, Y., et al. 2020. ACS Chem Neurosci. 11: 1353-1358. PMID: 32271540
- The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model. | Kim, HJ., et al. 2022. Arch Pharm Res. 45: 51-62. PMID: 34984603
- Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis. | Świerczek, A., et al. 2022. J Pharmacol Exp Ther. 381: 151-163. PMID: 35221290
- Correction to 'PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure'. | Chen, Y., et al. 2022. ACS Chem Neurosci. 13: 2346-2347. PMID: 35839516
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRL-50481, 10 mg | sc-201178 | 10 mg | $72.00 | |||
BRL-50481, 50 mg | sc-201178A | 50 mg | $272.00 |