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BRL 15572 hydrochloride is a selective SR-1D antagonist, displaying 60-fold selectivity over SR-1B, and exhibiting little or no affinity for a range of other receptor types.
1. Hagan, J J., et al., 1997. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. European journal of pharmacology. 331(2-3): 169-74. PMID: 9274976
2. Price, G W., et al., 1997. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 312-20. PMID: 9303567
3. Schlicker, E., et al., 1997. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 321-7. PMID: 9303568
4. Saxena, P R., et al., 1998. 5-HT1-like receptors: a time to bid goodbye. Trends in pharmacological sciences. 19(8): 311-6. PMID: 9745358
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