BRL 15572 hydrochloride CAS: 193611-72-2
MF: C25H27ClN2O•HCl
MW: 443.42
A selective SR-1D antagonist.

BRL 15572 hydrochloride (CAS 193611-72-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 134ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride
Application: A selective SR-1D antagonist
CAS Number: 193611-72-2
Purity: >98%
Molecular Weight: 443.42
Molecular Formula: C25H27ClN2O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BRL 15572 hydrochloride is a selective SR-1D antagonist, displaying 60-fold selectivity over SR-1B, and exhibiting little or no affinity for a range of other receptor types.


References

1. Hagan, J J., et al., 1997. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. European journal of pharmacology. 331(2-3): 169-74. PMID: 9274976
2. Price, G W., et al., 1997. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 312-20. PMID: 9303567
3. Schlicker, E., et al., 1997. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 321-7. PMID: 9303568
4. Saxena, P R., et al., 1998. 5-HT1-like receptors: a time to bid goodbye. Trends in pharmacological sciences. 19(8): 311-6. PMID: 9745358

Physical State :
Solid
Solubility :
Soluble in Hot water (5 mg/ml), DMSO (>40 mg/ml), and ethanol (50 mM).
Storage :
Desiccate at 4° C
Melting Point :
188.0-190.0° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 10 µM; SR-1D: IC50 = 260 µM
Ki Data :
SR-1D: Ki= 12.59 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
TL7767100
PubChem CID :
11957475
MDL Number :
MFCD09878288
SMILES :
C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 160ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 18ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.