Molecular structure of BRL 15572 hydrochloride, CAS Number: 193611-72-2
BRL 15572 hydrochloride (CAS 193611-72-2)
Alternate Names:
3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride
Application:
BRL 15572 hydrochloride is a selective SR-1D antagonist
CAS Number:
193611-72-2
Purity:
>98%
Molecular Weight:
443.42
Molecular Formula:
C25H27ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BRL 15572 hydrochloride is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.
BRL 15572 hydrochloride (CAS 193611-72-2) References
- Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. | Honda, M., et al. 2003. Eur J Pharmacol. 482: 155-61. PMID: 14660017
- Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. | Calama, E., et al. 2005. Clin Exp Pharmacol Physiol. 32: 894-900. PMID: 16173953
- Serotonergic modulation of murine fundic tone. | Xue, L., et al. 2006. Am J Physiol Gastrointest Liver Physiol. 291: G1180-6. PMID: 16873894
- Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart. | García, M., et al. 2007. Clin Exp Pharmacol Physiol. 34: 1199-206. PMID: 17880377
- Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin. | Tubío, RI., et al. 2010. J Exp Biol. 213: 1813-21. PMID: 20472767
- The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity. | Vinuela-Fernandez, I., et al. 2014. Neuropharmacology. 79: 136-51. PMID: 24269608
- Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. | Hagan, JJ., et al. 1997. Eur J Pharmacol. 331: 169-74. PMID: 9274976
- SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. | Price, GW., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 312-20. PMID: 9303567
- Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. | Schlicker, E., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 321-7. PMID: 9303568
- 5-HT1-like receptors: a time to bid goodbye. | Saxena, PR., et al. 1998. Trends Pharmacol Sci. 19: 311-6. PMID: 9745358
Inhibitor of:
PKC, and SR-1D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRL 15572 hydrochloride, 5 mg | sc-202979 | 5 mg | $100.00 |