BRL 15572 hydrochloride CAS: 193611-72-2
MF: C25H27ClN2O•HCl
MW: 443.42
A selective SR-1D antagonist.

BRL 15572 hydrochloride (CAS 193611-72-2)

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Synonym: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride
Application: A selective SR-1D antagonist
CAS Number: 193611-72-2
Purity: >98%
Molecular Weight: 443.42
Molecular Formula: C25H27ClN2O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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BRL 15572 hydrochloride is a selective SR-1D antagonist, displaying 60-fold selectivity over SR-1B, and exhibiting little or no affinity for a range of other receptor types.


1. Hagan, J J., et al., 1997. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. European journal of pharmacology. 331(2-3): 169-74. PMID: 9274976
2. Price, G W., et al., 1997. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 312-20. PMID: 9303567
3. Schlicker, E., et al., 1997. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn-Schmiedeberg's archives of pharmacology. 356(3): 321-7. PMID: 9303568
4. Saxena, P R., et al., 1998. 5-HT1-like receptors: a time to bid goodbye. Trends in pharmacological sciences. 19(8): 311-6. PMID: 9745358

Physical State :
Solubility :
Soluble in Hot water (5 mg/ml), DMSO (>40 mg/ml), and ethanol (50 mM).
Storage :
Desiccate at 4° C
Melting Point :
188.0-190.0° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 10 µM; SR-1D: IC50 = 260 µM
Ki Data :
SR-1D: Ki= 12.59 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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